Blood Component Separation Apparatus Using Hematocrit Correction
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Solution Overview
Problem
Existing blood component separation devices face challenges in accurately collecting platelet liquid at target concentrations due to low measuring accuracy of hematocrit values from blood cell counters, leading to either under or over-concentration of platelets.
Innovation Solution
A blood component separation device that includes a centrifugal separator and a calculation unit to correct hematocrit values using data from previous operations, ensuring accurate extracorporeal circulation volumes and target concentrations are met, regardless of the measuring accuracy of the blood cell counter.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If hematocrit value is measured with a blood cell counter, then the extracorporeal circulation volume can be adjusted, but the measuring accuracy is low leading to incorrect platelet concentration
Solution Approach 1:
The system uses feedback from actual collected platelet liquid concentration data to continuously update and refine the hematocrit correction values. The calculation unit stores correction values from previous operations and applies them to adjust the target extracorporeal circulation volume, creating a closed-loop feedback system that improves measurement accuracy over time despite initial blood cell counter inaccuracies.
Solution Approach 2:
The system changes the parameter used for volume calculation from the raw measured hematocrit value to a corrected hematocrit value that incorporates empirical correction factors. By transforming the hematocrit parameter through correction based on actual performance data, the system compensates for the blood cell counter's measurement errors and achieves accurate platelet concentration control.
2Productivity
If the target extracorporeal circulation volume is calculated from measured hematocrit value, then the collecting operation can be performed, but the collected platelet liquid may not satisfy the target concentration
Solution Approach 1:
The system performs preliminary correction of the hematocrit value before calculating the target extracorporeal circulation volume. By applying correction values derived from previous operations to the measured hematocrit value in advance, the system ensures that the subsequent collection operation starts with accurate parameter settings, thereby achieving both high productivity and precise concentration control.
Solution Approach 2:
The system incorporates feedback from actual collection results to refine future volume calculations. The calculation unit uses stored correction values from completed operations to adjust the hematocrit correction for upcoming operations, creating a continuous improvement loop that maintains both efficient collection and accurate concentration control across multiple operations.
3Manufacturing precision
If hematocrit correction is performed using data from previous operations, then the target concentration accuracy is improved, but the device complexity increases
Solution Approach 1:
The system performs self-calibration by automatically generating and applying its own correction values without requiring external intervention or complex calibration equipment. The calculation unit uses data from its own previous operations to create correction factors, enabling the device to self-improve its accuracy while maintaining relatively simple hardware architecture.
Solution Approach 2:
The system creates a simplified digital model of the hematocrit measurement error through correction values that are stored and reused. Instead of attempting to physically measure or correct the blood cell counter's inaccuracies, the system copies the error pattern from previous measurements and applies compensating corrections, achieving high precision through computational rather than physical means.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures the collection of platelet liquid at target concentrations by continuously updating correction values based on previous operation data, improving accuracy and consistency in platelet concentration, regardless of the blood cell counter's measuring accuracy.
Implementation Method 1
a centrifugal separator configured to separate a plurality of blood components from blood
Data Source
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AI summary
A blood component separation device includes a centrifugal separator and a container for containing a predetermined blood component which is centrifugally separated and is configured to perform a plurality of steps of collecting a predetermined blood component which is separated. The blood component separation device includes a calculation unit which calculates an estimated extracorporeal circulation volume from a hematocrit value calculated by correcting a hematocrit value measured with a blood cell counter. The calculation unit calculates a correction value used in the correction from a data value of the estimated extracorporeal circulation volume of a plurality of immediately preceding collecting operations and a data value of sampled blood volume measured in the first cycle of each of the plurality of immediately preceding collecting operations.