Blood Separation Pipeline Switching for RBC Removal and Plasma Exchange
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Solution Overview
Problem
Conventional methods for blood cell component removal and plasma exchange in the Spectra Optia instrument are inflexible, leading to increased treatment time, high consumable consumption, and elevated costs due to separate operations, which limits the clinical applicability and reduces treatment effectiveness.
Innovation Solution
A device for freely switching between blood cell component removal and plasma exchange, incorporating a blood component separator, external exchange pathway, waste liquid collection bag, centrifugal separation belt, pipeline clamping plate, and various pumps and sensors, allowing simultaneous operation of multiple treatments using a single set of consumables.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If separate treatment methods (red blood cell removal, lymphocyte removal, plasma exchange) are performed separately using multiple sets of consumables, then each treatment can be performed with dedicated equipment, but the treatment time increases significantly and the economic burden on patients increases
Solution Approach 1:
The patent combines multiple separate treatment functions (red blood cell removal, lymphocyte removal, plasma exchange) into a single integrated blood component separation device. The device uses one set of consumables and one separation mechanism to perform all treatments simultaneously or sequentially, eliminating the need for multiple separate equipment sets and reducing overall treatment time while maintaining therapeutic effectiveness.
Solution Approach 2:
The blood component separation device is designed with multi-functionality to perform various blood component removal and plasma exchange operations through a single system. The device can selectively remove different blood components (red blood cells, lymphocytes, plasma) based on controlled conditions, providing universal treatment capability that replaces multiple specialized devices.
2Reliability
If multiple sets of consumables are prepared for separate treatments, then each treatment has dedicated resources, but the economic burden on patients increases and resource consumption increases
Solution Approach 1:
The patent merges the function of multiple consumable sets into a single integrated consumable system. The device uses one set of consumables to perform all blood component separation and plasma exchange functions, significantly reducing consumable consumption while maintaining treatment quality through controlled separation processes.
Solution Approach 2:
The consumable system is designed with universality to support multiple treatment functions simultaneously. A single consumable set can handle red blood cell removal, lymphocyte removal, and plasma exchange through the same separation mechanism, reducing the need for multiple specialized consumable sets.
3Device complexity
If the Spectra Optia instrument uses a conservative and strict pipeline design with cancelled manual operation modes, then the instrument structure is simplified and standardized, but the flexibility of adjusting plasma exchange and cell component removal is reduced
Solution Approach 1:
The patent introduces dynamic control capabilities into the otherwise standardized pipeline design. By adding controllable valves and flow regulation mechanisms, the system can dynamically adjust blood flow paths and separation parameters to achieve different treatment modes (plasma exchange, cell component removal) while maintaining the simplicity of the overall pipeline structure.
Solution Approach 2:
The patent achieves treatment flexibility through parameter changes rather than structural modifications. By controlling flow rates, pressure differentials, and separation conditions, the standardized pipeline can perform multiple treatment functions, maintaining device simplicity while achieving adaptability through programmable parameter adjustment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances clinical flexibility, reduces treatment time, and lowers costs by enabling simultaneous switching between blood cell removal and plasma exchange operations, optimizing the treatment process and expanding the instrument's clinical application range.
Implementation Method 1
a centrifugal separation belt
Data Source
AI summary
An optimizing device for freely switching RBC removal and plasma exchange are provided, which is used to solve the problems in the prior art that the treatment effect is poor, the consumption of consumables is excessive, and the application range is narrow. According to the device, an additional hanging hook is added, a plasma exchange output pipeline is modified to be separated from the plasma collection pump and to be installed to the additional hanging hook. Then, the RBC recirculation tube is clamped through a freely movable cassette, so that the flow rate control of a plasma collection pump is released. Thereafter, HCT data is adjusted, and liquid is compensated, so that the RBC removal or replacement, lymphoplasma exchange and plasma exchange can be freely switched, which can meet the clinical treatment needs, optimize the process and reduce the cost. Therefore, the application range of a pipeline is greatly increased.