Blood Separation Controller Platelet Aggregation Prevention
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Solution Overview
Problem
Conventional blood processing methods are inadequate in preventing platelet aggregation during platelet collection procedures, as they lack automated control to diagnose and counteract this issue, making it difficult for operators to predict and adjust process parameters effectively.
Innovation Solution
A blood processing system with a controller that determines the amount of platelets and predicts the likelihood of aggregation, adjusting operational parameters such as the whole blood-to-anticoagulant ratio or anticoagulant flow rate to prevent platelet aggregation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional blood processing methods are used, then the system is simple to operate, but platelet aggregation cannot be effectively prevented
Solution Approach 1:
The controller continuously monitors platelet concentration in the blood stream and uses this feedback to dynamically adjust anticoagulant flow rate and whole blood-to-anticoagulant ratio, preventing platelet aggregation through real-time closed-loop control
Solution Approach 2:
The system automatically determines platelet concentration and adjusts processing parameters without operator intervention, enabling the system to self-regulate and prevent platelet aggregation autonomously
2Reliability
If automated control is implemented to predict and prevent platelet aggregation, then platelet quality improves, but the device complexity increases
Solution Approach 1:
The system replaces manual operator diagnosis and adjustment with automated electronic control that uses optical detection and algorithm-based prediction to prevent platelet aggregation, substituting mechanical/operator-based processes with electronic automation
Solution Approach 2:
The controller dynamically changes processing parameters including anticoagulant flow rate and whole blood-to-anticoagulant ratio based on real-time platelet concentration measurements and aggregation likelihood predictions
3Productivity
If operator intervention is required to diagnose and adjust parameters, then the system remains simple, but processing time increases and effectiveness decreases
Solution Approach 1:
The system performs self-diagnosis and self-adjustment by automatically monitoring platelet concentration and modifying processing parameters without requiring operator knowledge or intervention, enabling autonomous operation
Solution Approach 2:
The automated monitoring and adjustment operates continuously throughout the blood processing procedure, ensuring uninterrupted prevention of platelet aggregation and maintaining optimal processing conditions throughout
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system automatically prevents platelet aggregation, ensuring higher quality and quantity of collected platelets by dynamically adjusting processing parameters, thereby improving the efficiency and effectiveness of blood component separation.
Implementation Method 1
separate whole blood, usually by centrifugation, into its various therapeutic components
Data Source
AI summary
Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.