Blood State Evaluation Device Using Dielectric Measurement
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Solution Overview
Problem
Current blood coagulability tests, such as PT-INR and APTT, primarily evaluate bleeding risks due to excess anti-coagulant administration, while failing to assess thrombus risks associated with enhanced coagulability, and existing methods like platelet aggregation tests are complicated and prone to inaccuracies due to centrifugation activation. Additionally, image diagnosis and biomarker methods lack sensitivity and specificity for predicting future thrombosis.
Innovation Solution
A blood state evaluation device and system that measures chronological changes in electrical characteristics of blood using dielectric measurements, analyzing permittivity changes to evaluate coagulation state and thrombosis risk through feature extraction and comparison with predetermined thresholds, enabling precise evaluation of thrombosis risk.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If PT-INR or APTT tests are used to evaluate blood coagulability, then bleeding risk assessment is improved, but thrombosis risk evaluation capability deteriorates
Solution Approach 1:
The dielectric measurement system performs multiple evaluation functions using a single measurement approach. By analyzing chronological changes in electrical characteristics at multiple frequencies, the system simultaneously assesses both bleeding risk (through coagulation time measurement) and thrombosis risk (through blood state evaluation), making the test universally applicable for comprehensive blood coagulability management
Solution Approach 2:
The invention evaluates different blood states by measuring electrical characteristics at multiple frequency points and analyzing chronological changes. By monitoring how electrical properties evolve over time during coagulation, the system can distinguish between normal coagulation, excessive coagulation (thrombosis risk), and insufficient coagulation (bleeding risk), thereby achieving both bleeding and thrombosis risk assessment through parameter variation analysis
2Measurement precision
If platelet aggregation test using PRP is performed, then platelet function evaluation is achieved, but operational complexity increases due to centrifugation requirement
Solution Approach 1:
The invention extracts only the essential measurement function from the complex platelet aggregation test protocol. By using dielectric measurement to directly assess blood state and platelet function without requiring centrifugation to prepare PRP, the system removes the complicated sample preparation step while retaining the ability to evaluate platelet function through chronological electrical characteristic changes
Solution Approach 2:
The invention replaces the mechanical centrifugation process with a non-mechanical dielectric measurement approach. Instead of using centrifugal force to separate plasma components for PRP preparation, the system uses electrical field interactions to directly measure blood properties, thereby eliminating the mechanical separation step and simplifying the overall test procedure
3Quantity of substance
If centrifugation process is used in platelet aggregation test, then platelet rich plasma is obtained, but platelet activation occurs during centrifugation reducing measurement accuracy
Solution Approach 1:
The invention extracts the measurement capability from the centrifugation-dependent PRP preparation process. By using dielectric measurement on whole blood or minimally processed samples, the system obtains platelet function information without requiring the centrifugation step that causes platelet activation, thereby maintaining both platelet concentration and measurement accuracy
4Measurement precision
If image diagnosis by ultrasonography or computed tomography is used, then diagnostic accuracy is improved, but ability to predict future thrombosis risk deteriorates
Solution Approach 1:
The invention performs preliminary assessment of thrombosis risk by evaluating blood state before actual thrombus formation occurs. Through chronological dielectric measurement of electrical characteristics, the system detects changes in blood coagulability and platelet function that precede thrombus development, enabling early intervention before the point where image diagnosis would be needed
Solution Approach 2:
The system provides continuous feedback on blood state through repeated dielectric measurements over time. By monitoring chronological changes in electrical characteristics, the system tracks the progression of coagulability changes and provides real-time assessment of thrombosis risk, allowing dynamic adjustment of monitoring frequency and intervention timing based on observed trends
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for easy and precise evaluation of thrombosis risk, reducing medical site load and improving sensitivity and specificity in predicting thrombosis, as demonstrated by high sensitivity and specificity scores in experimental results.
Implementation Method 1
measuring a chronological change in an electrical characteristic of the blood
Data Source
AI summary
A blood state evaluation device, blood state evaluation system, blood state evaluation method, and program that enable evaluation of the risk of thrombosis easily and precisely is provided. An electrical characteristic of blood being an evaluation target is chronologically measured in two or more frequencies or two or more frequency bands. On the basis of chronological change data of the measured electrical characteristic of the blood, a state of blood is evaluated.