Blood Unit Tests Kit Merging Typing and Quality Assessment
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Solution Overview
Problem
Current blood testing processes for donated blood are time-consuming and inefficient, failing to effectively assess blood quality and the survivability of red blood cells, which can lead to circulatory disorders and anemia due to inadequate flow properties and storage duration evaluation.
Innovation Solution
A diagnostic kit and system that combines blood typing, contaminating agent detection, and red blood cell quality assessment using a protein chip with antibodies and conjugated markers, enabling simultaneous testing of blood quality, storage duration, and survivability prediction on a single array, utilizing a glass slide with bound antibodies, lysis buffer, blocking buffer, wash buffer, and conjugated antibodies for specific detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple separate tests are performed for blood typing, contaminating agent detection, and RBC quality assessment, then each test can be conducted with specialized methods, but the overall testing process becomes time-consuming and inefficient
Solution Approach 1:
The patent combines multiple separate blood testing procedures (blood typing, contaminating agent detection, and RBC quality assessment) into a single integrated diagnostic kit. The kit includes a unified array substrate with multiple binding molecule regions that can simultaneously detect various blood parameters from one blood sample, eliminating the need for sequential separate tests and reducing overall testing time while maintaining measurement precision through specialized binding molecules for each parameter.
Solution Approach 2:
The diagnostic kit is designed as a universal platform that performs multiple blood testing functions through a single array system. The array substrate can detect blood type antigens, screen for contaminating agents, and assess RBC quality parameters all in one test run, making the system multi-functional and eliminating the need for multiple specialized test systems.
2Reliability
If traditional separate testing methods are used for blood bank tests, then each test can be optimized independently, but the overall process requires multiple procedures and increases operational complexity
Solution Approach 1:
The patent merges multiple independent blood testing procedures into a single integrated diagnostic kit with a unified array platform. This consolidation reduces operational complexity by eliminating the need for multiple separate procedures while maintaining reliability through the use of specific binding molecules for each test parameter and standardized detection protocols.
Solution Approach 2:
The diagnostic kit serves as a universal testing platform that handles blood typing, contaminating agent detection, and RBC quality assessment through one standardized procedure. This multi-functional approach simplifies operational workflows and reduces the complexity associated with managing multiple separate testing systems and procedures.
3Manufacturing precision
If conventional testing approaches are used, then standard procedures can be followed, but the ability to assess RBC flow properties and predict survivability is insufficient
Solution Approach 1:
The patent replaces complex mechanical or manual methods for assessing RBC flow properties with a biochemical detection system using specific binding molecules in an array format. This substitution enables precise measurement of RBC quality parameters including flow properties and survivability predictions through standardized biochemical interactions rather than difficult mechanical measurements.
Solution Approach 2:
The diagnostic kit enables the measurement of previously difficult-to-assess parameters such as RBC flow properties and survivability by transforming these complex biological properties into detectable biochemical signals through specific binding interactions. This allows for precise quantification of RBC quality parameters that were previously difficult to measure with conventional approaches.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides a rapid, reliable, and sensitive method to determine blood type, contaminating agents, and red blood cell quality, predicting survivability and optimal storage duration, thereby improving transfusion outcomes and reducing the risk of adverse reactions.
Implementation Method 1
a glass slide with an array of binding molecules (antibodies and proteins) bound thereon in predefined locations and pattern. The antibodies and proteins are targeting (or are targets of) known molecules
Implementation Method 2
set of conjugated marker-antibodies for specific detection
Data Source
AI summary
A diagnostic biological array, kit or system, and method of using same unit for conducting simultaneously blood tests and determining the presence of diseases, the blood type, and blood quality of a blood sample and its applications.