Blood Vessel Fluorescence Detection for AGE Monitoring
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Solution Overview
Problem
Existing methods for detecting fluorescence from AGEs in blood vessels are unreliable due to user-dependent measurement variations and unclear correlations with specific diseases, leading to inconsistent and ineffective data.
Innovation Solution
A device with an excitation light source and detecting section that specifically targets blood vessels to non-invasively detect fluorescence from AGEs, allowing for precise monitoring of vascular endothelial function and health conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the measurement position is left to user discretion, then the operation is simple and easy, but the measurement precision and reliability deteriorate due to variations in measurement positions and lack of blood vessel targeting
Solution Approach 1:
The patent uses fluorescence emission characteristics (color/wavelength changes) to identify and target blood vessels. The detecting section detects fluorescence emitted by blood vessel tissue when excited by the light source, allowing automatic identification of measurement positions without user discretion. This resolves the contradiction by maintaining ease of operation while improving measurement precision through optical property-based targeting.
2Device complexity
If fluorescence detection is performed without targeting blood vessels specifically, then the device complexity is reduced, but the reliability of health condition assessment deteriorates due to insufficient correlation with vascular diseases
Solution Approach 1:
The patent applies local quality by specifically targeting blood vessel tissue for fluorescence detection rather than general skin tissue. The detecting section is configured to detect fluorescence from blood vessel tissue excited by the light source, creating a localized measurement approach that improves reliability for vascular disease assessment while maintaining relatively simple device structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables reliable and daily monitoring of blood vessel health conditions, effectively addressing cardiovascular disorders such as diabetes and arteriosclerosis by providing accurate data related to vascular function.
Implementation Method 1
an excitation light source for exciting a blood vessel tissue of a living body; and a detecting section for detecting fluorescence from the blood vessel tissue excited by the excitation light source
Data Source
AI summary
The present invention detects a fluorescent signal from AGEs at a blood vessel tissue of an individual to determine the condition of the tissue of the individual. This solves a problem that in measurement of AGEs used in diagnosis of diabetes, data indicative of fluorescent spectrum from AGEs at the skin of a forearm varies depending on where to measure on skin of even the same forearm, which results in variations in measurement values, leading to unreliable data and incorrect measurement result.