Blue-Light Skin Protection Composition for Circadian Resynchronization
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Solution Overview
Problem
Excessive exposure to blue light, particularly from screens, causes skin aging, inflammation, and disrupts the circadian rhythm, with existing cosmetic products offering limited protection against its harmful effects.
Innovation Solution
A cosmetic or dermatological composition comprising chrysin, rosmarinic acid, and a peptide with the sequence GQPR or its derivatives, which synergistically inhibit inflammation, stimulate Opsin 5 production, and enhance melatonin production to counteract blue light's negative effects while promoting its beneficial effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blue light is used for circadian rhythm synchronization, then beneficial effects on skin function are improved, but harmful effects such as oxidative stress and inflammation increase
Solution Approach 1:
The patent applies this principle by using melatonin and its derivatives, which are known antioxidants, to counteract the harmful oxidative effects of blue light. The composition converts the harmful ROS production into a beneficial effect by enhancing the skin's antioxidant defense system, thereby protecting against blue light-induced damage while maintaining circadian rhythm benefits
Solution Approach 2:
The patent uses antioxidants (melatonin, vitamin C, vitamin E) as intermediary substances that mediate between blue light exposure and skin cells. These intermediaries absorb or neutralize the harmful effects of blue light before they can damage cellular structures, while allowing the beneficial circadian synchronization to proceed
2Reliability
If existing cosmetic products are used for blue light protection, then some protective effect is provided, but protection against harmful effects is limited
Solution Approach 1:
The patent applies this principle by creating a composite cosmetic formulation that combines multiple active ingredients with different mechanisms of action: melatonin (antioxidant and circadian regulator), vitamins C and E (antioxidants), and peptides (skin repair). This composite approach provides comprehensive protection against multiple blue light-induced damage pathways simultaneously
Solution Approach 2:
The patent merges several protective functions into a single cosmetic composition: antioxidant protection, anti-inflammatory action, circadian rhythm support, and skin repair. By combining these functions in one product, it overcomes the limitation of existing single-function products and provides comprehensive blue light protection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces oxidative stress, inflammation, and skin degradation, enhances skin hydration and tone, and resynchronizes the circadian rhythm by stimulating Opsin 5 and melatonin production, thereby mitigating the adverse effects of blue light exposure.
Implementation Method 1
They are necessary for the organism to produce relaxing endorphins and for daily resynchronization of the circadian rhythm... This beneficial effect is manifested in particular by an action at the level of opsins (OPN) which are membrane proteins that capture light energy
Implementation Method 2
Blue light stimulates the production of H 2 O 2 and oxygenated free radical species (ROS) by peroxisomes and mitochondria
Implementation Method 3
It has a direct antioxidant effect which reduces the toxicity of chemical molecules
Implementation Method 4
It stimulates the mitochondrial electronic transport chain and the associated ATP production with consequently a decrease in the H 2 O 2 production
Implementation Method 5
melatonin can stimulate the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase and glutathione peroxidase involved in the detoxification of H 2 O 2
Data Source
AI summary
The composition comprises or consists of chrysin, rosmarinic acid, at least one peptide or derivative thereof, having a sequence of 4 to 10 amino acids comprising the active sequence GQPR and a physiologically acceptable medium. A derivative corresponds to said peptide modified at the N-terminal end with an acyl (-CO-R1), sulfonyl (-SO2-R1) group or a biotinoyl group and/or at the C-terminal end with an OR1, NH2, NHR1 group or NR1R2, R1 and R2 being, independently of one another, chosen from an alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclic, polycyclic, unsaturated, hydroxyl, carbonyl, phosphorylated and/or sulfur-containing, said group having from 1 to 24 carbon atoms and possibly having in its backbone one or more O, S and/or N heteroatoms. Such a composition acts on the effects of light radiation on the skin and/or of its appendages, and more particularly the effects of blue light. It helps to fight against the harmful effects and in a particularly advantageous manner at the same time to increase the beneficial effects by resynchronizing the circadian cycle.