Autologous Bone Marrow Stromal Cell Graft for Turbinate Reconstruction
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Solution Overview
Problem
Current treatments for empty nose syndrome (ENS) following inferior turbinate overexcision are inadequate, leading to complications such as rejection, allergy, and histocompatibility issues with existing filling materials, necessitating a more effective tissue-engineered bone graft for reconstruction.
Innovation Solution
A tissue-engineered bone graft comprising a decalcified bone matrix carrier with human bone marrow stromal stem cells (BMSCs), optimized for specific decalcification degree and thickness, combined with in vitro culture methods to create a bioactive composite for autologous reconstruction of the inferior turbinate.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional filling materials (silicone, autologous or allogeneic bone, cartilage, artificial dermis, hydroxyapatite) are used to treat empty nose syndrome, then a certain therapeutic effect can be achieved, but rejection, allergy, and histocompatibility problems occur
Solution Approach 1:
The invention uses autologous bone marrow stromal stem cells (BMSCs) that belong to the patient themselves, eliminating rejection and histocompatibility issues. The decalcified bone matrix carrier is also derived from the patient's own bone, creating a fully autologous graft that the body will not reject or react allergically to, while still providing the structural support needed for therapeutic effect
Solution Approach 2:
The invention creates a composite tissue-engineered bone graft combining decalcified bone matrix carrier with autologous BMSCs. This composite structure provides both the mechanical support of the bone matrix and the biological regenerative capacity of living stem cells, achieving therapeutic effect while avoiding the complications of traditional materials
2Ease of operation
If inferior turbinate is overexcised to treat nasal obstruction, then nasal ventilation is improved, but empty nose syndrome develops with secondary atrophy of nasal mucosa
Solution Approach 1:
The invention prepares a tissue-engineered bone graft with autologous BMSCs and decalcified bone matrix before implantation. This pre-prepared graft ensures that when the inferior turbinate is reconstructed, there is already a viable tissue structure in place to prevent secondary atrophy of the nasal mucosa, rather than waiting for atrophy to occur and then attempting treatment
Solution Approach 2:
The invention changes the physical and biological parameters of the turbinate reconstruction by using a tissue-engineered graft with specific decalcification degree (95-85%) and controlled BMSC concentration (1×10^7 to 1×10^8 cells/cm³). These parameter optimizations ensure the graft provides adequate structural support while promoting mucosal regeneration and preventing atrophy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The graft provides a safe, immunogenic, and effective solution for repairing inferior turbinate defects, promoting nasal mucosa repair, improving nasal ventilation, and reducing the risk of complications associated with existing treatments.
Implementation Method 1
a decalcified bone matrix carrier; wherein, The decalcification degree of the decalcified bone matrix carrier is 95-85%
Implementation Method 2
human bone marrow stromal stem cells (BMSCs)
Data Source
AI summary
Provided is a tissue engineered bone graft used in inferior turbinate reconstruction. In particular, provided is a tissue engineered bone graft comprising a bone marrow stromal cell (BMSC) grown on a demineralized bone matrix. The tissue engineered bone graft is used in inferior turbinate reconstruction. The tissue engineering bone graft of the present invention may effectively reconstruct the inferior turbinate, has no immunogenicity, and has high safety.