BNCT Irradiation-Time Correction Using Actual Blood Boron
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing boron neutron capture therapy (BNCT) systems face challenges in accurately controlling irradiation doses due to discrepancies between preset and actual blood boron concentrations, leading to prolonged treatment times, increased costs, and reduced system utilization.
Innovation Solution
A BNCT system that includes an image acquisition module, detecting module, treatment planning module, processing module, and correction module to generate a preset treatment plan, establish a functional relationship between blood boron concentrations and dose rates, and correct irradiation time based on actual blood boron concentrations, thereby omitting pre-treatment drug injections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If a preset blood boron concentration is used for simulation and calculation to estimate irradiation time, then treatment expenses are reduced and treatment process is simplified, but there will be an error in the treatment plan when the preset concentration differs from the actual blood boron concentration
Solution Approach 1:
The system performs simulation and calculation using preset blood boron concentrations before actual treatment to estimate irradiation time. This preliminary action allows treatment planning to be completed in advance without waiting for actual concentration measurements, simplifying the treatment process while maintaining acceptable accuracy through subsequent real-time monitoring and adjustment during irradiation.
2Measurement precision
If simulation and calculation are performed again according to the actual blood boron concentration to obtain a new treatment plan, then treatment plan accuracy is improved, but total treatment time is prolonged and system utilization rate is reduced
Solution Approach 1:
The system implements real-time monitoring of blood boron concentration during irradiation and uses this feedback to dynamically adjust treatment parameters. This allows the system to maintain high treatment plan accuracy without requiring complete re-simulation, as the initial preset-based plan is continuously refined based on actual measured concentrations, thereby avoiding prolonged treatment times and maintaining high system utilization.
3Reliability
If the boron-containing drug is injected continuously to maintain blood boron concentration, then irradiation dose control is improved, but treatment cost increases and treatment process becomes more complex
Solution Approach 1:
The system employs dynamic adjustment of irradiation parameters based on real-time blood boron concentration monitoring. Rather than requiring continuous drug injection to maintain constant concentration, the system adapts the neutron beam parameters and irradiation timing to match the actual pharmacokinetics of boron delivery, achieving reliable dose control with a simpler treatment protocol.
Data Source
AI summary
Provided is a boron neutron capture treatment system. The boron neutron capture treatment system includes an image acquiring module for acquiring a medical image of an irradiated body, a detecting module for detecting the actual concentration of blood boron in the irradiated body, a treatment planning module for generating a preset treatment plan on the basis of medical image data, a processing module for acquiring a functional relationship between the concentration of blood boron and a dose rate on the basis of the preset treatment plan and a plurality of groups of preset concentrations of blood boron, and a correction module. The correction module obtains a corrected irradiation time on the basis of the functional relationship and the actual concentration of blood boron, such that a boron-containing medicament can be prevented from being injected into a patient before treatment, thereby saving the treatment cost and simplifying the treatment process.