Lactobacillus Gasseri BNR17 Composition for Climacteric Symptom Relief

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Solution Overview

Problem

Existing treatments for climacteric syndrome, such as estrogen supplementation, have significant side effects, while plant-derived Sophora japonica fruit extracts are limited in their efficacy and scope, necessitating a more effective and safer alternative.

Innovation Solution

A pharmaceutical and functional food composition utilizing Lactobacillus gasseri BNR17 as an active ingredient, optionally combined with Sophora japonica extract, to treat and prevent climacteric symptoms like osteoporosis, involutional depression, pain hypersensitivity, and vaginal dryness.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If estrogen supplementation therapy is used to treat climacteric syndrome, then climacteric symptoms are alleviated, but serious side effects occur including uterine bleeding, breast cancer, strokes, and uterine cancer

Engineering Contradiction:

Improveefficacy in alleviating climacteric symptomsVSAvoidside effects such as uterine bleeding, breast cancer, strokes, and uterine cancer

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces long-term estrogen supplementation with a short-term probiotic intervention using Lactobacillus gasseri BNR17. The probiotic bacteria provide temporary but effective relief of climacteric symptoms through local action in the vaginal environment, eliminating the need for continuous hormone exposure that causes serious side effects

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent introduces Lactobacillus gasseri BNR17 as an intermediary organism that mediates the treatment of climacteric symptoms. Instead of directly administering estrogen that causes harmful effects, the probiotic bacteria serve as a biological mediator that restores vaginal health and alleviates symptoms through fermentation and acid production, creating a safe indirect treatment pathway

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If plant-derived Sophora japonica fruit extracts are used as an alternative to estrogen supplementation, then some climacteric symptoms are alleviated, but the efficacy and scope of treatment are limited

Engineering Contradiction:

Improveside effectsVSAvoidefficacy and scope of treatment

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent changes the fundamental parameter of treatment from plant extract chemicals to living probiotic bacteria. Lactobacillus gasseri BNR17 provides a broader spectrum of benefits including symptom relief, vaginal pH regulation, and prevention of infections, thereby expanding the efficacy and scope beyond what Sophora japonica extracts can achieve alone

Inventive Principle:

Principle #35Parameter changes

3Reliability

If Lactobacillus gasseri BNR17 is administered to treat climacteric syndrome, then multiple climacteric symptoms are effectively alleviated with minimal side effects, but the mechanism involves complex biological interactions in the vaginal environment

Engineering Contradiction:

Improvesafety profile with minimal side effectsVSAvoidcomplexity of biological mechanism in vaginal environment

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs Lactobacillus gasseri BNR17 as a self-service therapeutic agent that autonomously performs multiple functions in the vaginal environment. The probiotic bacteria self-regulate vaginal pH through acid production, compete with pathogenic organisms, and alleviate symptoms without requiring external control mechanisms, thereby simplifying the overall treatment system despite the complex biological interactions involved

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Lactobacillus gasseri BNR17 effectively alleviates climacteric symptoms by improving bone density, reducing pain sensitivity, and enhancing vaginal moisture, with minimal side effects, and can be administered through various routes including oral and transdermal.

Implementation Method 1

Lactobacillus gasseri BNR17 derived from human breast milk is a lactic acid bacterium that exhibits strong acid resistance, bile resistance, and intestinal adhesion, so it inhabits the body and converts low-saccharide carbohydrates degraded by digestive enzymes into high-molecular-weight polysaccharide materials that are not absorbed in the body to thus discharge the same

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentEP4108249B1Composition for treating climacteric disorder comprising lactobacillus gasseri BNR17

Publication Date: 2026.01.28 ACEBIOME INC

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AI summary

The present invention relates to a pharmaceutical composition for treating climacteric disorder, containing Lactobacillus gasseri BNR17 as an active ingredient, and a functional food composition for preventing or ameliorating climacteric symptoms, containing Lactobacillus gasseri BNR17 as an active ingredient. Lactobacillus gasseri BNR17 according to the present invention has an excellent effect of treating, preventing, or ameliorating various climacteric symptoms, such as amelioration of osteoporosis, which is the representative symptom of climacterium, amelioration of involutional depression, amelioration of pain hypersensitivity, and amelioration of vaginal dryness.