Body Fluid Collection Device With Integrated Hermetic Filter
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Solution Overview
Problem
Existing body fluid collection devices often require additional processing steps to isolate specific components for analysis, which can be time-consuming and prone to contamination, especially when dealing with low concentrations of cell-free DNA or pathogenic nucleic acids in blood samples.
Innovation Solution
A body fluid collection device featuring a tube with a filter that can be hermetically sealed, designed to selectively remove specific components from the fluid during collection, such as inflammatory substances or white blood cells, using a filter with a flange and interference fit mechanism to ensure effective filtration without affecting the collected sample.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a full body fluid collection device is used to collect all components in the body fluid, then the collected body fluid contains all necessary components for analysis, but additional processing steps are required to remove interfering components before detection
Solution Approach 1:
The filter is pre-installed in the tube body before body fluid collection, enabling interfering components to be removed during the collection process itself rather than requiring separate post-collection processing steps. This preliminary filtration action eliminates the need for subsequent centrifugation or chemical treatment steps.
Solution Approach 2:
The filtration function is merged with the body fluid collection device by integrating the filter directly into the tube body structure. This combination allows simultaneous collection and filtration of body fluid in a single integrated device, eliminating the need for separate collection and processing steps.
2Measurement precision
If additional processing steps are performed to remove interfering components from body fluid, then detection sensitivity is improved, but the risk of sample contamination increases
Solution Approach 1:
Interfering components are removed during the collection process itself through the integrated filter, rather than through subsequent processing steps. This preliminary filtration occurs in a controlled environment before the sample leaves the collection device, minimizing exposure to contamination risks during handling and processing.
Solution Approach 2:
The body fluid collection device performs its own filtration function through the integrated filter, removing interfering components autonomously during collection. This self-service capability eliminates the need for external processing equipment and manual intervention, thereby reducing contamination risks from additional handling steps.
3Measurement precision
If chemical reagents are used to remove interfering components from body fluid, then detection accuracy is improved, but the process becomes time-consuming and may cause sample loss
Solution Approach 1:
Interfering components are physically extracted and removed from the body fluid through mechanical filtration by the integrated filter during collection. This physical extraction method eliminates the need for time-consuming chemical reagent treatments and associated waiting periods for chemical reactions to complete.
Solution Approach 2:
The chemical reagent-based removal process is replaced with a mechanical filtration system. The integrated filter uses physical filtration mechanisms rather than chemical reactions, dramatically reducing processing time and eliminating the need for additional chemical treatment steps.
4Reliability
If the filter is integrated into the tube body with hermetic connection, then filtration effectiveness is improved, but the device complexity increases
Solution Approach 1:
The filter is merged with the tube body through direct integration, where the filter forms an integral part of the tube structure. This merging approach achieves hermetic connection and effective filtration while avoiding the need for separate filter components and complex assembly mechanisms.
Solution Approach 2:
The filter is implemented as a thin film or membrane structure integrated into the tube body wall, allowing hermetic filtration without adding significant structural complexity. This thin film approach maintains the simplicity of the overall device while achieving effective separation of interfering components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This device allows for targeted filtration of specific components, improving analysis sensitivity, reducing sample contamination, and simplifying the analysis process by removing interfering components during collection, thus enhancing the accuracy and efficiency of tests like NIPT and NGS.
Implementation Method 1
a filter, the filter is arranged in the tube body for filtering specific components from the body fluid to be collected
Data Source
AI summary
The present disclosure relates to a body fluid collection device (1), the body fluid collection device (1) comprises a tube body (10), wherein the tube body (10) is used to contain the collected body fluid and is provided with an opened end (12); a tube plug (20), wherein the tube plug (20) is configured to be able to hermetically close the opened end (12) of the tube body (10); and a filter (30), wherein the filter (30) is arranged in the tube body (10) for filtering out specific components from a body fluid to be collected, wherein the filter (30) is configured to be capable of being attached to the tube plug (20) at the open end, and the tube plug (20) is hermetically connected to the filter (30).