Bondable Blood-Friendly Polymer Coating for Medical Devices
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Solution Overview
Problem
Conventional blood-friendly polymers face limitations due to hydrophobic chain units that reduce blood-friendliness and physical coatings' instability, making them unsuitable for wide-ranging applications.
Innovation Solution
A novel terpolymer or quadripolymer synthesized by copolymerization of polyethylene glycol alkyl ether acrylate or methacrylate with zwitterionic acrylic ester, acrylic acid derivatives, and specific functional groups, enabling self-cross linkage and bonding with matrices, enhancing blood-friendliness and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If hydrophobic chain units are used to improve water insolubility and blending property, then coating stability is improved, but blood-friendliness is reduced
Solution Approach 1:
The patent applies local quality by incorporating hydrophilic chain units (polyethylene glycol, zwitterionic groups) at specific locations within the polymer structure to provide blood-friendliness, while maintaining hydrophobic segments for coating stability. This creates a heterogeneous polymer structure where different regions perform different functions.
Solution Approach 2:
The patent creates a composite polymer structure combining multiple functional units: polyethylene glycol alkyl ether acrylate/methacrylate for solubility and blendability, zwitterionic acrylic ester/methacrylic ester for blood-friendliness, and acrylic acid/methacrylate derivatives with bondable groups for adhesion. This composite approach resolves the contradiction between hydrophobic stability and hydrophilic blood-friendliness.
2Ease of operation
If physical coating is used to simplify application process, then ease of operation is improved, but coating stability deteriorates due to dissolution
Solution Approach 1:
The patent applies self-service through self-crosslinking mechanisms where the polymer contains bondable functional groups (trimethoxysilyl, epoxypropyl, isocyanate, hydroxyalkyl, propargyl, or quaternary ammonium groups) that automatically form crosslinks after coating application, transforming the physical coating into a chemically bonded network that resists dissolution.
Solution Approach 2:
The patent changes the chemical state parameter of the coating from physical adhesion to chemical crosslinking. The bondable functional groups undergo chemical reactions to form covalent bonds, fundamentally changing the coating's stability characteristics from reversible physical attachment to irreversible chemical bonding.
3Stability of the object's composition
If bondable functional groups are added to enable self-crosslinking and matrix bonding, then coating stability and versatility are improved, but polymer structure complexity increases
Solution Approach 1:
The patent applies universality by designing a polymer system where a single copolymer structure performs multiple functions: polyethylene glycol units provide solubility and blendability, zwitterionic units provide blood-friendliness, and bondable functional groups provide adhesion and crosslinking capability. This multi-functional design reduces the need for separate components.
Solution Approach 2:
The patent merges multiple functional requirements into a single terpolymer or quadripolymer structure. Instead of using separate polymers for solubility, blood-friendliness, and adhesion, the invention combines all these functions into one integrated copolymer system, simplifying the overall coating formulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymer exhibits improved blood-friendliness, stability, and versatility for various applications, including medical devices and coatings, by self-crosslinking and bonding with matrices, reducing platelet adhesiveness and enhancing bio-friendliness and resistance to biological contamination.
Implementation Method 1
it also can be bonded firmly by self-cross linkage or the bonding with matrix after construction
Implementation Method 2
bonding with matrix after construction
Data Source
AI summary
A bondable blood-friendly polymer is a terpolymer or a quadripolymer at least formed by polyethylene glycol alkyl ether acrylate or polyethylene glycol alkyl ether methacrylate (I), and zwitterionic acrylic ester or zwitterionic methacrylic ester (II), and acrylic acid or a methacrylate derivative with an epoxypropyl group, an isocyanate group, a trialkoxy silane, a hydroxyalkyl group, a propargyl group or a quaternary ammonium group (III). In the present invention, the blood-friendly polymer with a potentially-bondable group has the following advantages: although the water insolubility thereof is implemented by using the hydrophobicity physical effect of an existing higher alkyl acrylate linkage, the blood friendliness of a coating is reduced due to the existence of a great number of hydrophobic chain links in the polymer; and a physical coating is slowly desolventized from the surface to be ablated in the application process of the physical coating. A disclosed bondable blood-friendly polymer coating not only can overcome these defects, but also can improve the blending property thereof. Disclosed are composition, a structure and a preparation method of the bondable blood-friendly polymer.