Bone Adhesive Compositions for Fixation with Limited Bone Volume
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Solution Overview
Problem
Current fixation methods for attaching bone fragments or artificial devices to the bony skeleton rely on mechanical means, which are limited by bone volume and density, and require bone remodeling for long-term stability, often compromising fixation due to anatomical or disease-related factors.
Innovation Solution
An adhesive composition comprising a multivalent metal salt and a small organic phosphate compound that adheres to bone surfaces, allowing for rapid hardening and resorption, maintaining volume, and providing structural support through adhesion, which can be molded and applied in layers to achieve desired shapes and sizes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If mechanical fixation devices (screws, pins, anchors, plates, rods) are used to attach bone fragments or artificial devices to the bony skeleton, then fixation strength is achieved through mechanical means, but the method is limited by bone volume and density and requires bone remodeling for long-term stability
Solution Approach 1:
The patent replaces mechanical fixation systems (screws, pins, plates) with a chemical adhesion system based on adhesive compositions containing polyacrylic acid and its salts. The adhesive forms strong chemical bonds with bone surfaces through acid-base interactions and chelation with calcium ions, eliminating the need for mechanical anchoring in drilled holes or reamed cavities. This substitution enables effective fixation even in bones with limited volume or density where mechanical devices cannot be properly anchored.
Solution Approach 2:
The patent utilizes changes in the chemical and physical parameters of the adhesive composition to achieve optimal fixation. The polyacrylic acid-based adhesive exhibits pH-dependent adhesion properties, allowing it to bond effectively to bone surfaces across varying physiological conditions. The adhesive's viscosity and setting characteristics can be modified through formulation adjustments, enabling adaptation to different surgical applications and bone conditions, including cases with limited bone volume or density.
2Reliability
If bone cement or other materials are used to lute prostheses to bone, then adhesion is achieved, but the existing volume and density of bone must be sufficient to house and retain the attachment elements
Solution Approach 1:
The patent replaces mechanical interlocking systems with chemical adhesion mechanisms. The polyacrylic acid-based adhesive forms molecular-level bonds with bone surfaces through acid-base interactions and calcium chelation, creating reliable adhesion without requiring sufficient bone volume to house mechanical attachment elements. This enables prosthetic fixation in cases where bone quantity is insufficient for traditional cementation or mechanical anchoring.
Solution Approach 2:
The adhesive composition acts as an intermediary material between the prosthesis and the bone surface. It creates a strong chemical bond interface that transfers loads effectively without requiring the bone itself to provide mechanical retention features. The adhesive's ability to chelate calcium ions and form stable complexes with bone minerals creates a reliable bonding interface even when bone volume or density is limited.
3Duration of action of moving object
If resorbable devices are used to mechanically attach items to host bone structure, then gradual replacement by bone occurs allowing healing, but fixation depends on the balance of bone formation and resorption processes
Solution Approach 1:
The patent replaces mechanical fixation devices with a chemical adhesion system that provides immediate and reliable bonding independent of bone remodeling rates. The polyacrylic acid-based adhesive creates strong chemical bonds that remain stable throughout the healing process, eliminating the uncertainty associated with timing the replacement of resorbable devices. Fixation reliability is maintained throughout the entire healing period without depending on the balance between bone formation and resorption.
Solution Approach 2:
The adhesive composition provides self-sustaining fixation that does not require active management or timing coordinated with bone remodeling processes. Once bonded, the adhesive maintains fixation stability independently of whether bone is being formed or resorbed at any given time. This eliminates the need to coordinate device replacement with specific stages of bone healing, providing continuous reliable fixation throughout the entire healing period.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive composition effectively stabilizes bone fragments and artificial devices by adhering to bone surfaces, maintaining volume, and allowing for precise placement and rapid hardening, while being resorbed by the body over time, enhancing fixation and stability without relying on bone remodeling.
Implementation Method 1
an adhesive composition comprising a multivalent metal salt and a small organic phosphate compound that adheres to bone surfaces
Implementation Method 2
allowing for rapid hardening and resorption, maintaining volume
Implementation Method 3
the body has the ability to replace the material through biological processes with natural bone over time
Data Source
AI summary
The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.