Bone Bioactive Composition for Dental Implant Integration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current dental implants face challenges with improper engraftment and failure, leading to loss, and there is a need for effective treatments for periodontal diseases like peri-implantitis and periodontitis, which cause bone tissue destruction.
Innovation Solution
A bone bioactive composition comprising a water-based salt solution with specific concentrations of sodium dihydrogen phosphate, sodium chloride, potassium hydrogen phosphate, potassium chloride, calcium salt, and a chelating agent, which promotes osteogenesis and accelerates bone formation, enhancing implant integration and treating periodontal diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional implant surfaces are used without modification, then the implant can be manufactured and implanted, but the engraftment is improper and implant failure occurs
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition and surface properties of the implant through exposure to phosphate-buffered saline solutions with specific pH ranges (6.5-7.5) and compositions containing calcium and phosphate ions. This transforms the surface chemistry to enhance osteoblast adhesion and bone integration, directly resolving the engraftment failure issue while using a relatively simple treatment process
Solution Approach 2:
The patent uses phosphate-buffered saline solution as an intermediary substance that mediates between the implant surface and bone tissue. The solution contains calcium phosphate compounds that act as intermediaries to promote protein adsorption and osteoblast attachment, facilitating proper engraftment without requiring complex direct surface modifications
2Reliability
If the implant surface is modified to improve protein binding and osteointegration, then implant engraftment improves, but the treatment time and process complexity increase
Solution Approach 1:
The patent applies preliminary action by pre-treating the implant surface with phosphate-buffered saline solution containing calcium and phosphate ions before implantation. This preliminary modification creates a surface layer that is optimized for protein binding and osteoblast adhesion, ensuring improved osteointegration from the outset without requiring extended treatment periods or post-implantation interventions
Solution Approach 2:
The patent utilizes parameter changes by controlling the pH (6.5-7.5), ionic composition (calcium and phosphate concentrations), and exposure duration of the phosphate-buffered saline solution. These optimized parameters achieve effective surface modification that enhances osteointegration within a practical time frame, balancing treatment efficacy with process efficiency
3Reliability
If standard bone formation time is required for implant integration, then natural bone formation processes occur, but the treatment duration is extended to three months
Solution Approach 1:
The patent applies parameter changes by modifying the chemical environment at the implant-bone interface through phosphate-buffered saline treatment. The specific pH range (6.5-7.5) and ionic composition accelerate osteoblast proliferation and bone matrix deposition, reducing the integration time from three months to a significantly shorter period while maintaining bone formation quality
Solution Approach 2:
The patent uses calcium phosphate compounds in the phosphate-buffered saline solution as intermediaries that accelerate the bone formation process. These intermediaries provide a biochemical environment that stimulates faster osteogenesis and bone remodeling, thereby increasing productivity without compromising the quality of bone integration
4Ease of operation
If no surface treatment is applied, then the implant can be implanted immediately, but periodontal diseases like peri-implantitis and periodontitis cause bone tissue destruction
Solution Approach 1:
The patent applies preliminary anti-action by pre-treating the implant surface with phosphate-buffered saline solution to create a protective surface layer that resists periodontal pathogens and inflammatory damage. This preliminary protective measure reduces susceptibility to peri-implantitis and periodontitis, counteracting harmful factors before they can cause bone tissue destruction
Solution Approach 2:
The patent uses parameter changes in the phosphate-buffered saline treatment (pH 6.5-7.5, calcium and phosphate ion concentrations) to create a surface composition that enhances resistance to periodontal diseases. The modified surface properties reduce bacterial adhesion and inflammatory response, protecting against harmful effects while maintaining ease of implantation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly accelerates bone formation and integration of dental implants, reducing the time for proper engraftment from three months to 15 days, and effectively treats periodontal diseases by promoting early and increased bone generation.
Implementation Method 1
A bone bioactive composition comprising a water-based salt solution with specific concentrations of sodium dihydrogen phosphate, sodium chloride, potassium hydrogen phosphate, potassium chloride, calcium salt, and a chelating agent, which promotes osteogenesis and accelerates bone formation
Data Source
AI summary
A bone bioactive composition and kits comprising the composition, means for applying it and/or a metal implant are provided. The bone bioactive composition comprises a water-based salt solution comprising sodium dihydrogen phosphate and sodium chloride, and may also comprise additional elements. The composition and the kits are useful for promoting osteogenesis, particularly when a metal implant is used but also in case of periodontal diseases.