Shape-Stable Bone Cement with Residual Hydraulic Activity

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Solution Overview

Problem

Existing bone replacement materials lack remaining hydraulic activity, which is desirable for enhanced bioactivity and osteogenic stimulation, and often require high-temperature sintering processes that impair bioactivity and resorbability.

Innovation Solution

Dimensionally stable shaped bone replacement bodies made of mineral bone cement with remaining hydraulic activity are produced by mixing reactive mineral bone cement with a poorly water-soluble carrier liquid, shaping via 3D printing or granulation, and contacting with an aqueous solution or steam-saturated environment to initiate setting, allowing for controlled hydration and interruption of the setting process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If high-temperature sintering processes (>500°C) are used to produce calcium phosphate bone replacement materials, then material similarity to bone minerals is improved, but structure coarsening occurs which impairs bioactivity and resorbability

Engineering Contradiction:

Improvematerial similarity to bone mineralsVSAvoidstructure fineness

Core Design Contradiction:

Stability of the object's compositionVSManufacturing precision

Solution Approach 1:

The invention changes the temperature parameter from high-temperature sintering (>500°C) to low-temperature processing (below sintering temperature), thereby preserving fine structure while achieving bone-like material composition through controlled precipitation and setting reactions

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention replaces the mechanical/thermal sintering process with a chemical precipitation and hydraulic setting process, allowing bone-like material formation at low temperatures without structural coarsening

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Stability of the object's composition

If mineral bone cement is completely set before implantation to ensure dimensional stability, then storage and transport stability is improved, but remaining hydraulic activity is lost which reduces bioactivity and osteogenic stimulation

Engineering Contradiction:

Improvedimensional stabilityVSAvoidbioactivity

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The invention performs preliminary shaping and partial setting before implantation, achieving sufficient dimensional stability for handling while retaining remaining hydraulic activity to enable post-implantation bioactivity and osteogenic stimulation

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The invention creates a dynamic state where the bone cement is partially set with controlled remaining hydraulic activity, allowing the material to transition from a stable storage state to an active biological state after implantation through controlled water contact

Inventive Principle:

Principle #15Dynamics

3Manufacturing precision

If water-free pasty preparations are used for 3D printing bone replacement bodies, then shaping precision is improved, but setting reaction cannot proceed without water contact which delays hardening

Engineering Contradiction:

Improveshaping accuracyVSAvoidhardening time

Core Design Contradiction:

Manufacturing precisionVSDuration of action of moving object

Solution Approach 1:

The invention performs preliminary shaping of the bone cement in a water-free or low-water state for precision, then initiates the setting reaction after implantation through controlled contact with aqueous environment or steam, achieving both precision and timely hardening

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The approach results in bone replacement bodies with sufficient mechanical strength for storage and implantation, while maintaining hydraulic activity for enhanced bioactivity and osteogenic stimulation, allowing for complete hardening post-implantation under biological conditions.

Implementation Method 1

Mineral bone cements are a special form and have a hydraulic setting reaction in situ Harden

Methodology Applied

Scientific EffectHydraulic setting reaction: Mineral Hydration

Implementation Method 2

termination of the setting process by the substantial removal of water

Methodology Applied

Scientific EffectEvaporation: Evaporation

Data Source

PatentEP3060268B1Shape-stable bone replacement moulded element with residual hydraulic activity

Publication Date: 2018.11.21 INNOTERE

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AI summary

The invention relates to shape-stable bone replacement moulded elements made of mineral bone cement with residual hydraulic activity, which contain at least a proportion of set mineral bone cement and at least a proportion of unreacted or unset reactive mineral bone cement, wherein the proportion of set mineral bone cement is 5 to 90% by weight. The shape-stable bone replacement moulded elements comprise at least 5% of the maximum strength value of a fully set bone cement, consisting of the same mineral components and having the same structural features, and achieve compressive strengths in the range from 2 to 200 MPa. They are substantially anhydrous and can be reacted under biological conditions.