Bone Cement Kit with Osteogenic Matrix for Bone Bonding
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Solution Overview
Problem
Conventional PMMA-based bone cement is non-biodegradable, non-porous, and unfavorable to bone cell growth, leading to disrupted interfaces and potential disengagement in long-term use during surgeries like percutaneous vertebroplasty.
Innovation Solution
A bone cement composition kit comprising a bone matrix component and a hydrogel component, with the bone matrix being osteogenic and mixed with PMMA-based cement, allowing for adjustable mechanical properties and enhanced bone tissue formation, using a dual-cylinder device for controlled polymerization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If PMMA-based bone cement is used, then mechanical strength is improved, but biocompatibility and bone bonding capability deteriorate
Solution Approach 1:
The patent creates a composite bone cement system by combining PMMA-based bone cement with bone marrow substitute particles. The bone marrow substitute serves as a filler component that provides osteogenic properties while the PMMA matrix maintains mechanical strength. This composite approach allows both materials to contribute their advantageous properties to the final bone cement composition.
2Ease of operation
If PMMA-based bone cement is used, then ease of operation is improved, but long-term stability deteriorates
Solution Approach 1:
The patent applies local quality by creating a heterogeneous structure where bone marrow substitute particles are distributed within the PMMA matrix. The bone marrow substitute regions provide osteogenic functionality and improved interfacial bonding with surrounding bone tissue, while the PMMA regions maintain ease of handling and injection properties. This local differentiation of material properties resolves the contradiction between ease of operation and long-term stability.
3Productivity
If conventional PMMA-based bone cement is used, then productivity is improved, but biodegradability deteriorates
Solution Approach 1:
The patent modifies the compositional parameters of the bone cement by incorporating bone marrow substitute particles at controlled concentrations (30-70 wt%). This parameter change enables the cement to gain biodegradability and osteogenic properties while maintaining the rapid setting characteristics and ease of application of PMMA-based cements. The specific composition ratio optimizes both productivity and biodegradability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The kit facilitates bone tissue formation, improves mechanical properties, and extends the operating time of the cement, making it suitable for various orthopedic surgeries by incorporating an osteogenic bone matrix with PMMA-based cement, addressing the limitations of conventional PMMA-based bone cement.
Implementation Method 1
the hydrogel component comprises an acrylic polymer and an acrylic monomer
Data Source
AI summary
The present invention provides a bone cement composition kit. The bone cement composition kit includes a bone matrix component and a hydrogel component, respectively stored in separate containers, wherein the bone matrix component includes a bone matrix, the hydrogel component includes an acrylic polymer and an acrylic monomer. A ratio of the bone matrix component to the hydrogel component is in a range from about 1:2 (mL/mL) to about 1:50 (mL/mL).