Bone Cement Composition with Optimized Contrast Medium Particle Size
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional compositions for hard tissue repair, such as bone cements, often suffer from inadequate penetration into cancellous bone, leading to gaps and osteolysis, which can cause pain and require revision surgery.
Innovation Solution
A composition for hard tissue repair is developed, utilizing a contrast medium with a specific volume mean particle diameter range, along with a (meth)acrylate-based monomer and polymer, and a polymerization initiator, to enhance penetration and adhesion, as measured by simulated bone penetrability and adhesion to pig femur tests.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional bone cement compositions are used, then the composition can be applied for hard tissue repair, but the penetration into cancellous bone is insufficient leading to gaps and osteolysis
Solution Approach 1:
The patent changes the particle size parameter of the contrast medium to a specific range (volume mean particle diameter of 3.0 to 25.1 μm, preferably 3.0 to 18.0 μm) to optimize penetration into cancellous bone while maintaining adhesion. This parameter optimization resolves the contradiction between sufficient penetration and preventing gap formation.
Solution Approach 2:
The patent creates a composite composition combining (meth)acrylate-based monomer, (meth)acrylate-based polymer, polymerization initiator, and contrast medium particles. This composite formulation achieves both deep penetration into cancellous bone and strong adhesion, preventing osteolysis while maintaining structural integrity.
2Reliability
If contrast medium with small particle diameter is used, then penetration into bone may improve, but adhesion and mechanical strength may deteriorate
Solution Approach 1:
The patent identifies and optimizes the particle diameter parameter of the contrast medium to a specific range (volume mean particle diameter of 3.0 to 25.1 μm). This optimized parameter range simultaneously achieves deep penetration into cancellous bone and strong adhesion, resolving the contradiction between penetration and strength.
Solution Approach 2:
The patent applies local quality by having the contrast medium particles distributed throughout the composition matrix, with each particle contributing to both penetration (through small size) and adhesion (through surface interaction with bone tissue). The specific particle size range ensures local optimization of both properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition demonstrates improved penetration and adhesion to bone tissue, reducing the risk of osteolysis and the need for revision surgery, with barium sulfate or zirconia as effective contrast mediums, and organic boron compounds as preferred initiators for better tissue compatibility.
Implementation Method 1
a composition for hard tissue repair containing a (meth)acrylate-based monomer (A), a (meth)acrylate-based polymer (B), a polymerization initiator (C)
Data Source
AI summary
Disclosed are: a composition for hard tissue repair with excellent penetrability to an adherend such as a cancellous bone and excellent adhesion to an adherend, which comprises a monomer (A), a polymer (B), a polymerization initiator (C) and a contrast medium (X) having a volume mean particle diameter of 3 µm or more; and a kit for hard tissue repair having members in which the components of the monomer (A), the polymer (B), the polymerization initiator (C) and the contrast medium (X) contained in this composition for hard tissue repair are encased in three or more divided groups in an optional combination.