Demineralized Bone Fiber Pellets for Cannula Delivery
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Solution Overview
Problem
Current bone graft delivery methods face challenges with graft materials binding within cannulae, making it difficult to advance them through long, small-diameter tubes, leading to increased surgical time, costs, and risks of tissue damage during minimally invasive procedures.
Innovation Solution
A bone graft material is developed by demineralizing bone fibers, forming them into pellets that are coherent and lubricious, allowing for easy advancement through cannulae, with optional surface annealing to enhance cohesiveness and lubricity, and controlled rehydration properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If bone graft materials are delivered through long, small-diameter cannulae in minimally invasive surgery, then surgical trauma is reduced and recovery time is minimized, but the graft materials bind within the cannulae making them difficult to advance
Solution Approach 1:
The patent changes the physical parameters of the bone graft material by controlling fiber length (1-10 mm), fiber diameter (1-10 micrometers), and density (0.1-1.0 g/cm³) to create a composition that flows freely through cannulae without binding, while maintaining osteoinductive and osteoconductive properties
Solution Approach 2:
The patent creates a composite bone graft material combining demineralized bone fibers with specific organic matrix components and growth factors, forming a cohesive yet flowable composition that delivers multiple therapeutic functions through the cannula without mechanical binding issues
2Loss of time
If the incision size is minimized to reduce surgical trauma, then patient recovery time is reduced, but the graft must be delivered through relatively long cannulae of small diameter which causes binding
Solution Approach 1:
The patent optimizes the rheological parameters of the bone graft composition by controlling fiber size distribution, density, and composition to achieve a material that flows easily through long, narrow cannulae, simplifying the delivery system and enabling minimally invasive approaches
3Reliability
If conventional bone graft materials are used, then they provide osteoconduction and osteoinduction, but they bind within cannulae making surgical delivery difficult and increasing surgical time
Solution Approach 1:
The patent modifies the physical parameters of conventional bone graft materials by controlling fiber dimensions and density to create a composition that maintains biological efficacy while eliminating mechanical binding during delivery, thereby improving surgical efficiency
Solution Approach 2:
The patent formulates a composite bone graft material with specific fiber composition and structure that preserves osteoinductive and osteoconductive properties while adding flowability characteristics that prevent binding during minimally invasive delivery
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables efficient and controlled delivery of bone grafts through narrow tubes, reducing surgical trauma, costs, and improving graft placement, ensuring complete filling of defects and facilitating bone healing.
Implementation Method 1
the outermost layer of bone fibers which are annealed
Implementation Method 2
heating the mold to form a mold of bone fibers having an annealed outermost layer
Implementation Method 3
controlled rehydration properties
Data Source
AI summary
A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.