Demineralized Bone Fiber Interface for Stronger Screw Fixation
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Solution Overview
Problem
Modern surgical techniques face challenges in achieving and maintaining fixation in osteoporotic bone, particularly in the case of fracture and/or deformity, as the bone-screw interface is typically the region most susceptible to loosening and failure, leading to catastrophic failure and refusal of surgery in osteoporotic patients.
Innovation Solution
The use of demineralized bone fiber (DBF) implants, which are placed at the interface between bone and tissue or in bone holes prior to screw insertion, providing a denser substance for secure fixation and promoting local bone growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pedicle screws are used for fixation in osteoporotic bone, then surgical stabilization can be achieved, but screw loosening and failure occur due to compromised bone strength
Solution Approach 1:
The invention uses a composite material comprising demineralized bone matrix (DBM) and bone morphogenetic protein (BMP) applied at the bone-screw interface. This composite enhances fixation reliability by combining the osteoinductive properties of BMP with the osteoconductive properties of DBM, creating a stronger interface in osteoporotic bone without requiring changes to the screw design or surgical technique.
2Strength
If PMMA cement is used to augment pedicle screw fixation, then pull-out strength increases up to 150%, but potential morbidities such as spinal canal extrusion or vascular flow obstruction occur
Solution Approach 1:
The invention employs an intermediary substance consisting of BMP and DBM applied at the bone-screw interface. This intermediary enhances screw fixation strength through biological mechanisms (osteoinduction and osteoconduction) rather than mechanical filling, thereby achieving increased pull-out strength without the harmful effects of cement extrusion into the spinal canal or obstruction of vascular flow.
3Ease of manufacture
If traditional screw fixation is used in compromised bone, then surgical procedure is simple, but initial fixation strength is insufficient leading to subsequent loosening and failure
Solution Approach 1:
The invention applies BMP and DBM to the bone surface before screw insertion as a preliminary action. This pre-treatment of the bone-screw interface with osteoinductive and osteoconductive materials enhances initial fixation strength and promotes subsequent bone growth, thereby improving both immediate and long-term fixation without complicating the surgical procedure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances screw fixation and integration, reducing the risk of screw dislodgment and facilitating long-term bone repair, especially in osteoporotic bone, by increasing insertion torque and promoting osteoinduction and osteoconduction.
Implementation Method 1
promoting local bone growth through osteoinduction and osteoconduction
Implementation Method 2
promoting local bone growth through osteoinduction and osteoconduction
Implementation Method 3
The DBF implants increase the insertion torque and pull-out force of screws
Data Source
AI summary
A composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into shapes that are used to augment rotator cuff and acl repair. Sheets of bone fibers may be used as an interface between bone and tissue, tendons, and/or ligaments. The physical presence of the fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation. A delivery system and methods of use are also provided.