Bone Graft Composite with Embedded DBM Particles
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Solution Overview
Problem
There is a need for DBM compositions and methods that can utilize non-fiber bone material for osteogenesis, osteoinduction, and osteoconduction while reducing waste and improving mechanical properties, as current methods face limitations in supply and efficiency with fiber-based demineralized bone matrices.
Innovation Solution
The development of implantable bone graft compositions combining fibers of demineralized bone matrix from allograft bone with non-allograft bone material, where non-fibrous demineralized bone matrix particles are embedded within or disposed on the fibers of non-allograft bone material, incorporating bioerodible polymers and ceramics, and using a method that involves mixing collagen and ceramic powder to form a slurry, drying, and embedding demineralized bone matrix particles within or on the fibers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If fiber-based demineralized bone matrix is used for implantation, then mechanical properties such as cohesiveness and fiber structure are improved, but bone material supply is limited and non-fiber bone material is wasted
Solution Approach 1:
The patent changes the physical form parameter of bone material from exclusively fiber-based to include both fiber and non-fiber particles. By incorporating non-fiber demineralized bone matrix particles (110-850 microns) into the composite graft, the invention utilizes previously wasted material while maintaining mechanical integrity through the fiber component.
Solution Approach 2:
The patent creates a composite bone graft material combining fiber-based demineralized bone matrix with non-fiber demineralized bone matrix particles. This composite structure allows the fiber component to provide mechanical strength and cohesiveness while the non-fiber particles contribute additional osteoinductive and osteoconductive properties, reducing overall bone material waste.
2Loss of substance
If non-fiber bone material particles are used, then material waste is reduced, but mechanical properties and cohesiveness are insufficient
Solution Approach 1:
The patent merges fiber-based demineralized bone matrix with non-fiber demineralized bone matrix particles into a single composite graft material. The fiber component provides the necessary mechanical strength and cohesiveness, while the non-fiber particles are incorporated to utilize previously wasted bone material, achieving both goals simultaneously.
Solution Approach 2:
The patent applies different components to different functional requirements within the same graft: fiber-based demineralized bone matrix is used to provide mechanical strength and structural integrity, while non-fiber demineralized bone matrix particles are incorporated to maximize material utilization and provide osteoinductive properties, with each component serving its optimal function.
3Reliability
If allograft bone fibers are used for osteogenesis and osteoinduction, then bone formation is promoted, but the supply is limited due to donor availability and regulatory constraints
Solution Approach 1:
The patent makes the bone graft composition multi-functional by combining allograft bone fibers (which provide osteogenesis and osteoinduction) with non-fiber demineralized bone matrix particles and synthetic osteoinductive factors. This allows the graft to perform multiple functions - promoting bone formation through multiple mechanisms - while reducing dependence on limited allograft supply.
Solution Approach 2:
The patent introduces synthetic osteoinductive factors as intermediaries that can substitute for or supplement the limited allograft bone material. These synthetic factors mediate the osteoinductive process, reducing the need for donor bone while maintaining reliable bone formation promotion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach results in a bone graft material that is osteoinductive, osteoconductive, and osteogenic, with improved mechanical properties, reducing waste and enhancing bone regeneration by providing a scaffold for new bone formation, and is compatible with the body's natural processes for resorption and remodeling.
Implementation Method 1
The second is osteoinduction, a process in which molecules contained within the graft (e.g., bone morphogenic proteins and other growth factors) convert progenitor cells into bone-forming cells
Implementation Method 2
The third is osteoconduction, a physical effect by which a matrix often containing graft material acts as a scaffold on which bone and cells in the recipient are able to form
Implementation Method 3
the implantable composition will generally be implanted by surgery... compatible with the body's natural processes for resorption and remodeling
Data Source
AI summary
Osteoinductive and osteoconductive compositions for bone graft which utilize less allograft tissue, and methods for their production, are provided. The compositions and methods contain a combination of fibers of demineralized bone matrix from allograft bone and fibers of non-allograft bone material. The fibers of non-allograft bone material comprise non-fibrous demineralized bone matrix particles embedded within or disposed on the fibers of non-allograft bone material. The non-allograft fibers of the composition contain a bone void filler of collagen and one or more ceramics embedded with demineralized bone matrix particles. In some embodiments, the composition also contains a bioactive agent.