Weight-Controlled Bone Graft Application for Porosity and Dosage
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Solution Overview
Problem
Current bone graft materials fail to deliver consistent and reliable results due to inadequate porosity, mechanical integrity, and rate of biodegradation, leading to suboptimal clinical outcomes, and pose challenges in handling and dosage control, especially with pliable and compressible materials.
Innovation Solution
Methods for determining a target quantity of bone graft material based on porosity and defect-specific requirements, using compressible and expandable materials with calculated target porosity values to ensure consistent application and optimal clinical results, including packaging by weight and using charts or algorithms for precise dosage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If bone graft materials are made pliable and compressible for easier handling, then ease of operation is improved, but manufacturing precision and dosage control deteriorate
Solution Approach 1:
The patent applies parameter changes by controlling the density and porosity of the bone graft material to resolve the contradiction between ease of handling and dosage control. The material is engineered with specific density ranges (0.2-0.8 g/cm³) and porosity levels (60-90%) that allow it to be compressible and easy to handle while maintaining precise dosage control through weight-based packaging. This enables the material to be molded into desired shapes during surgery without compromising the accuracy of the administered dose.
2Reliability
If bone graft materials degrade quickly to allow new tissue emergence, then biocompatibility is improved, but duration of action worsens
Solution Approach 1:
The patent resolves this contradiction through parameter changes by formulating the bone graft material with controlled degradation kinetics. The material is designed with specific porosity (60-90%) and density (0.2-0.8 g/cm³) parameters that enable it to maintain structural integrity and mechanical support during the critical early healing phase, then degrade at a controlled rate that matches bone tissue formation. This ensures biocompatibility through appropriate degradation timing while extending the duration of mechanical support when needed.
3Reliability
If porosity is increased to allow vascularization, then biocompatibility is improved, but mechanical integrity worsens
Solution Approach 1:
The patent applies parameter changes by optimizing the porosity parameter within a specific range (60-90%) and controlling density (0.2-0.8 g/cm³) to resolve the contradiction between vascularization and mechanical integrity. The interconnected pore structure within this optimized porosity range allows adequate vascularization and nutrient transport while the controlled density maintains sufficient mechanical strength to support new bone growth. The material's compressibility further allows adaptation to mechanical loads during healing.
4Adaptability or versatility
If bone graft materials are customized for each patient's anatomical site, then adaptability is improved, but device complexity worsens
Solution Approach 1:
The patent applies segmentation by dividing the bone graft material into pre-packaged units with specific weight ranges (0.1-10 grams per package). This segmentation allows clinicians to select and combine packages to match the specific requirements of each anatomical defect without requiring complex custom manufacturing for each patient. The material itself can be further segmented or molded into the defect site, providing customization while simplifying the overall application process through standardized packaging units.
Data Source
AI summary
Methods of providing dose controlled application of bone graft materials are disclosed. In particular, methods for determining a target quantity of bone graft material for clinical application in order to ensure maximum clinical results are provided. These methods comprise determining the target weight of the material to be applied.