Multi-compartment Bone Graft Delivery System for Osteogenic Activity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current bone graft delivery systems, such as those using demineralized bone matrix (DBM), face challenges with rapid degradation of active factors, leading to short-lived osteogenic activity, which limits their effectiveness in bone healing processes, as they primarily induce bone growth along the surface rather than throughout the graft material.
Innovation Solution
A delivery system comprising a covering with separate compartments that allows for the mixing of DBM particles with other therapeutic agents like autograft material and growth factors before or during surgical procedures, ensuring these agents are in close contact to enhance bone growth throughout the graft material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If DBM particles are used as a delivery system, then osteogenic activity is initially high, but the active factors degrade rapidly within 24 hours, limiting bone growth induction to only the surface area
Solution Approach 1:
The delivery system is segmented into multiple compartments, with at least one compartment containing DBM particles and another compartment containing therapeutic agents. This segmentation allows the therapeutic agents to be released in proximity to the DBM particles, extending the duration of osteogenic activity beyond the rapid degradation period of DBM alone and expanding the volume of bone growth induction throughout the graft material rather than仅限于 the surface.
2Device complexity
If DBM particles are delivered alone, then the structure is simple, but the osteogenic activity is short-lived and limited to surface bone growth
Solution Approach 1:
The invention merges DBM particles with other therapeutic agents (such as growth factors, bone marrow aspirate, or stem cells) within a single delivery system comprising multiple compartments. This combination enhances the reliability and consistency of bone growth by providing multiple osteogenic mechanisms working synergistically, while the integrated multi-compartment structure maintains manageable complexity through a unified delivery vehicle.
3Ease of operation
If additional therapeutic agents are placed separately from DBM (underneath or on top of mesh bag), then the delivery system is easier to assemble, but bone growth is induced primarily along the surface rather than throughout the graft material
Solution Approach 1:
The delivery system employs a nested compartment structure where at least one compartment containing therapeutic agents is positioned in proximity to or within the structure containing DBM particles. This nesting arrangement ensures that therapeutic agents are released in close contact with DBM particles throughout the graft material volume, inducing bone growth throughout the entire volume rather than only along the surface, while maintaining ease of assembly through a pre-configured integrated structure.
Data Source
AI summary
A delivery system comprising a covering having at least two compartments is provided. A first compartment contains a first therapeutic agent and the second compartment can be unfilled and is configured to receive a second therapeutic agent. The first compartment and the second compartment are separated by at least one removable separation member, for example a drawstring, that can be pulled to allow the first and second therapeutic agents to mix prior to delivery at a selected surgical site. Either the first or second compartment of the covering define an opening further comprising a pre-attached sealing member, which can be a flap sealable by heat, sutures, pressing or interference fittings. The opening of the empty compartment can be configured to receive a filling member, such as a funnel fitted with a spring loaded clip for temporary attachment to the covering. A method of treating a bone defect in a patient utilizing the delivery system is also provided.