Bone Graft Putty with Composite Binder for Malleability and Cohesiveness
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Solution Overview
Problem
Current bone graft substitutes lack effective malleability and cohesiveness, and fail to efficiently conduct bone growth based on native signals or administer signal molecules at the implant site, limiting their ability to promote tissue growth effectively.
Innovation Solution
A malleable medical implant composition comprising noncollagenous scaffolding elements, sulfated glycosaminoglycan molecules, and a biocompatible liquid organic binder, along with osteoconductive calcium-containing particulate material, which enhances cohesivity and supports bone growth by incorporating osteoinductive proteins like bone morphogenic protein.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If traditional bone graft substitutes are used, then bone defect treatment is provided, but the materials lack effective malleability and cohesiveness
Solution Approach 1:
The invention uses a composite material system combining hydroxyapatite particles (osteconductive phase) with a collagen-carboxymethyl cellulose binder system (organic matrix). This composite structure provides both malleability through the flexible binder and cohesiveness through the interlocked hydroxyapatite network, resolving the contradiction between ease of operation and reliability.
Solution Approach 2:
The invention modifies the physical and chemical parameters of the bone graft substitute by controlling the particle size distribution of hydroxyapatite (combining fine and coarse particles), adjusting the collagen-to-carboxymethyl cellulose ratio, and optimizing the water content. These parameter changes enable the material to achieve optimal malleability while maintaining cohesiveness.
2Reliability
If scaffolding material is added to conduct bone growth, then bone growth conduction is improved, but handling effectiveness during implantation deteriorates
Solution Approach 1:
The invention creates local quality variations within the bone graft substitute by incorporating hydroxyapatite particles of different sizes (fine particles for osteoinduction, coarse particles for structural scaffolding). The collagen-CMC binder matrix provides uniform distribution while the hierarchical particle structure ensures both handling effectiveness and bone growth conduction capabilities.
3Reliability
If the composition is made more cohesive, then shape retention is improved, but malleability deteriorates
Solution Approach 1:
The invention creates a dynamic material system where the collagen-carboxymethyl cellulose binder provides time-dependent behavior. During implantation, the material exhibits high malleability allowing easy shaping. After implantation, the binder sets and provides shape retention. This dynamic transition resolves the contradiction between malleability and shape retention.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides a cohesive, shape-retaining putty that effectively promotes bone growth by maintaining structural integrity and releasing osteoinductive factors, enhancing bone ingrowth and fusion in orthopedic and spinal fusion procedures.
Implementation Method 1
a liquid organic binder that coats the scaffolding elements, wherein the liquid organic binder has a viscosity and is present in an amount that is effective to increase the cohesivity of the mechanically entangled mass of scaffolding elements
Implementation Method 2
The composition comprises sulfated glycosaminoglycan molecules bound to the scaffolding elements
Implementation Method 3
the sulfated glycosaminoglycan can exhibit the capacity to bind the osteoinductive protein
Data Source
AI summary
In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.