Calcium Phosphate Bone Graft Putty With Iron Imaging Excipients
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Solution Overview
Problem
Existing bone graft materials, such as autologous, allograft, and synthetic options, pose risks of pain, infection, disease transmission, graft rejection, and lower osteoconductive and osteoinductive properties, necessitating a safer and more effective synthetic alternative.
Innovation Solution
A bone graft composition comprising calcium phosphate putty with biphasic calcium phosphate particles, collagen, and optional additives like iron excipients, hardening agents, and antimicrobial agents, designed to enhance osteoconduction, osteoinduction, and bioavailability, with controlled delivery of active agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autologous bone graft material is used, then osteoconductive and osteoinductive properties are improved, but patient pain and risk of infection increase due to additional surgery
Solution Approach 1:
The patent employs synthetic bone graft materials that serve as temporary scaffolds for bone regeneration. These synthetic materials (such as calcium phosphate, beta-tricalcium phosphate, and hydroxyapatite) are designed to be gradually replaced by natural bone tissue over time, eliminating the need for additional surgical harvesting of autologous bone while providing the necessary osteoconductive and osteoinductive properties during the healing process.
Solution Approach 2:
The patent utilizes composite bone graft compositions that combine multiple synthetic materials with different properties. For example, mixtures of calcium phosphate and beta-tricalcium phosphate are employed to achieve both structural support and biological activity. These composite materials can be engineered to provide optimal mechanical strength, porosity, and surface area for bone cell attachment and growth, matching the performance of autologous grafts without the associated surgical risks.
2Reliability
If allograft bone material is used, then osteoconductive properties are improved, but risk of disease transmission and graft rejection increase
Solution Approach 1:
The patent employs synthetic bone graft materials that serve as temporary scaffolds for bone regeneration. These synthetic materials (such as calcium phosphate, beta-tricalcium phosphate, and hydroxyapatite) are designed to be gradually replaced by natural bone tissue over time, eliminating the need for additional surgical harvesting of autologous bone while providing the necessary osteoconductive and osteoinductive properties during the healing process.
Solution Approach 2:
The patent uses synthetic inorganic materials that are biologically inert in terms of immune response. Materials like calcium phosphate, beta-tricalcium phosphate, and hydroxyapatite do not provoke graft rejection or transmit diseases because they are not biological tissues. These materials provide a safe, controlled environment for bone regeneration without the immunological risks associated with allografts.
3Object-affected harmful factors
If synthetic bone graft material is used, then risk of microbial infection is reduced, but osteoconductive and osteoinductive properties are lowered
Solution Approach 1:
The patent employs porous synthetic bone graft materials with controlled pore sizes and interconnected pore structures. These porous materials provide high surface area for bone cell attachment, proliferation, and differentiation. The porosity allows nutrient diffusion and waste removal, creating a favorable environment for osteoconduction and osteoinduction while maintaining the synthetic material's inherent resistance to microbial infection.
Solution Approach 2:
The patent utilizes composite bone graft compositions that combine multiple synthetic materials with different properties. For example, mixtures of calcium phosphate and beta-tricalcium phosphate are employed to achieve both structural support and biological activity. These composite materials can be engineered to provide optimal mechanical strength, porosity, and surface area for bone cell attachment and growth, matching the performance of autologous grafts without the associated surgical risks.
4Productivity
If bone graft material is designed for fast curing, then surgical time is reduced, but control over curing rate and bioavailability becomes more difficult
Solution Approach 1:
The patent employs synthetic bone graft materials with adjustable physical and chemical parameters. The curing rate, porosity, particle size distribution, and surface area can be precisely controlled during manufacturing to optimize both surgical handling and biological performance. For example, the particle size and porosity of calcium phosphate materials can be tuned to achieve desired curing rates while maintaining adequate bioavailability and osteoconductive properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides improved bone regeneration, enhanced bioavailability, and antimicrobial properties, facilitating safer and more effective bone repair with controlled agent delivery and easy detection.
Implementation Method 1
the iron excipient serves as a chromogenic agent to enable visualization of adequate mixing and location of the putty relative to adjacent bone
Implementation Method 2
The iron excipient also serves as a contrast agent for x-radiographic imaging
Implementation Method 3
a hardening agent, an agent that controls the rate of curing
Data Source
AI summary
A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.