Demineralized Bone Implant With Donor-Bound BMPs for Spinal Fusion

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Solution Overview

Problem

Existing bone grafts and spinal implants lack sufficient bioactivity to effectively stimulate tissue growth and fusion, particularly in conditions like spinal instability or degenerative conditions.

Innovation Solution

Harvested bone tissue is processed to retain bone marrow and expose cells to lysing conditions, releasing growth factors like BMPs, which are then bound to the bone or a carrier, enhancing its osteoinductive properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If bone grafts are used to treat spinal instability or degenerative conditions, then bone fusion can be facilitated, but the implants lack sufficient bioactivity to effectively stimulate tissue growth

Engineering Contradiction:

Improvebone fusion effectivenessVSAvoidinsufficient bioactivity

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent combines multiple bioactive components (BMP-2, BMP-7, and other growth factors) within a single bone implant structure, merging the osteoinductive properties of different bone morphogenetic proteins to enhance overall bioactivity and stimulate more effective tissue growth and bone fusion

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The implant uses a composite structure combining demineralized bone matrix with bound bone morphogenetic proteins and other growth factors, creating a multi-component material system that provides both structural support and enhanced biological activity for improved bone regeneration

Inventive Principle:

Principle #40Composite materials

2Strength

If harvested bone fragments are used for grafting, then structural support is provided, but the osteoinductive properties are insufficient

Engineering Contradiction:

Improvestructural supportVSAvoidinsufficient osteoinductive properties

Core Design Contradiction:

StrengthVSObject-generated harmful factors

Solution Approach 1:

The patent merges structural bone fragments with bound bone morphogenetic proteins and growth factors, combining the mechanical strength and structural support of the bone matrix with the osteoinductive bioactivity of the bound proteins to achieve both structural integrity and enhanced bone formation capability

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting implants exhibit increased bioactivity, promoting effective tissue regeneration and fusion by stimulating new bone growth and differentiation.

Implementation Method 1

The harvested sample is exposed to a lysing agent or lysing conditions to lyse the cells within the harvested sample

Methodology Applied

Scientific EffectLysis:

Implementation Method 2

The lysate is added to the harvested sample and the released growth factors and nutrients bind to the harvested sample

Methodology Applied

Scientific EffectBinding: Adsorption

Data Source

PatentUS20260041815A1Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor

Publication Date: 2026.02.12 BIOVENTUS LLC

AI summary

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.