Bone Marrow Aspiration Device with Triggered Mixing
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Solution Overview
Problem
Inconsistent bone marrow aspiration due to varying force applications during the aspiration process, leading to reduced mesenchymal stem cell counts, especially when using larger volume syringes, which dilute the sample with peripheral blood.
Innovation Solution
A bone marrow aspiration device comprising multiple syringes with a series of sequential steps, including a first syringe for aspiration, a second syringe containing an anticoagulant, and a third syringe for mixing, utilizing one-way valves and triggers to control the aspiration and mixing process, ensuring consistent and high-quality bone marrow collection by maximizing mesenchymal stem cell content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a larger volume syringe is used to aspirate bone marrow, then the aspiration volume is increased, but the mesenchymal stem cell count is reduced due to blood dilution
Solution Approach 1:
The aspiration process is segmented into multiple sequential steps using three syringes: first syringe for initial aspiration, second syringe for anticoagulant addition, and third syringe for final collection. This segmentation allows controlled aspiration volumes while preventing blood dilution through timely anticoagulant addition.
Solution Approach 2:
Anticoagulant is prepared in advance in the second syringe and added to the bone marrow aspirate before blood dilution can occur. This preliminary action preserves mesenchymal stem cell concentration by preventing coagulation and blood mixing during the aspiration process.
2Productivity
If different pulling forces are applied to the syringe plunger, then the aspiration speed varies, but the bone marrow quality becomes inconsistent
Solution Approach 1:
The device incorporates a trigger mechanism that provides tactile feedback to the operator, ensuring consistent plunger pulling force across different users. The trigger's mechanical design creates a standardized resistance curve that guides the operator through the aspiration process with uniform force application.
Solution Approach 2:
The trigger mechanism automatically regulates the aspiration force and speed through its mechanical design, reducing dependence on operator skill and experience. The system self-corrects variations in pulling force by maintaining a consistent mechanical advantage throughout the aspiration stroke.
3Measurement precision
If a rapid forceful pull is applied to the plunger, then the mesenchymal stem cell content is maximized, but user technique variance increases
Solution Approach 1:
The trigger mechanism provides real-time tactile feedback that guides the operator to apply the correct rapid forceful pull. The mechanical design creates distinct resistance phases that signal the operator when optimal aspiration force is being applied, reducing technique variance while maintaining high mesenchymal stem cell recovery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device reduces user variance, improves bone marrow quality by maintaining high mesenchymal stem cell counts, and facilitates multiple collections by ensuring a consistent and efficient aspiration process.
Implementation Method 1
utilizing one-way valves and triggers to control the aspiration and mixing process
Data Source
AI summary
An embodiment of the invention is directed to a bone marrow aspiration device comprising a plurality of syringes, each of which operates in a series of sequential steps to obtain bone marrow of high quality and therapeutic value, i.e., having a high MSC/ml number. An embodiment of the invention preferably comprises three syringes, wherein a first syringe is used to aspirate bone marrow from a subject, a second syringe contains an anticoagulant, and the third syringe contains a mixture of the bone marrow aspirate and the anticoagulant.