Bone Marrow Aspiration Device Trigger Mechanism

Solution Overview

Problem

Inconsistent bone marrow aspiration due to varying force applications by operators results in reduced mesenchymal stem cell counts, particularly when using larger volume syringes, leading to lower quality bone marrow samples.

Innovation Solution

A bone marrow aspiration device comprising multiple syringes operating in sequential steps, with a trigger mechanism to control aspiration force and speed, and a system of valves to direct fluid flow, ensuring a rapid and consistent pulling force to maximize mesenchymal stem cell content, including the use of a smaller volume syringe and anticoagulant-coated collection syringe to prevent blood dilution.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If a larger volume syringe is used for bone marrow aspiration, then more bone marrow can be collected, but the mesenchymal stem cell count in the aspirate is reduced

Engineering Contradiction:

Improvebone marrow volumeVSAvoidmesenchymal stem cell count

Core Design Contradiction:

Quantity of substanceVSMeasurement precision

Solution Approach 1:

The aspiration process is divided into multiple sequential steps using multiple syringes. Each syringe aspirates a specific volume (1-4 ml) to optimize stem cell concentration, and the process is repeated to collect the required total volume. This segmentation allows maintaining high MSC/ml in each aspiration while accumulating the necessary total quantity.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The device employs repeated rapid application of pressure through the trigger mechanism to release pericyte-type mesenchymal stem cells from the vasculature. This periodic action is performed multiple times during the aspiration process to maximize stem cell content in each syringe fill, thereby maintaining high concentration even when using smaller volumes per syringe.

Inventive Principle:

Principle #19Periodic action

2Ease of operation

If different operators apply varying pulling force to the syringe plunger, then the operation is flexible, but the bone marrow aspiration quality becomes inconsistent

Engineering Contradiction:

Improveoperator flexibilityVSAvoidaspiration quality consistency

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The trigger mechanism is designed to provide a predetermined rapid pulling force that dynamically adapts to the operator's input. When the operator pulls the trigger, the mechanism delivers a standardized rapid force regardless of the operator's individual strength or technique, ensuring consistent aspiration quality while maintaining ease of operation.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The trigger mechanism transforms the operator's variable pulling force into a standardized rapid pulling action with consistent parameters. By changing the force parameter from variable (operator-dependent) to fixed (mechanism-controlled), the device ensures reliable and consistent bone marrow aspiration quality across different operators.

Inventive Principle:

Principle #35Parameter changes

3Ease of operation

If steady pressure is applied during bone marrow aspiration, then the procedure is simple, but mesenchymal stem cells (pericytes) are not effectively released

Engineering Contradiction:

Improveprocedure simplicityVSAvoidmesenchymal stem cell content

Core Design Contradiction:

Ease of operationVSMeasurement precision

Solution Approach 1:

The trigger mechanism is designed to provide a predetermined rapid pulling force that dynamically adapts to the operator's input. When the operator pulls the trigger, the mechanism delivers a standardized rapid force regardless of the operator's individual strength or technique, ensuring consistent aspiration quality while maintaining ease of operation.

Inventive Principle:

Principle #19Periodic action

Solution Approach 2:

The trigger mechanism transforms the operator's variable pulling force into a standardized rapid pulling action with consistent parameters. By changing the force parameter from variable (operator-dependent) to fixed (mechanism-controlled), the device ensures reliable and consistent bone marrow aspiration quality across different operators.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device reduces user variance, enhances bone marrow quality by increasing mesenchymal stem cell concentration, and facilitates multiple collections with improved ease and efficiency.

Implementation Method 1

the use of a smaller volume syringe and anticoagulant-coated collection syringe to prevent blood dilution

Methodology Applied

Scientific EffectAnticoagulant action:

Data Source

PatentUS10137227B2Bone marrow aspiration device

Publication Date: 2018.11.27 SPINESMITH PARTNERS LP

AI summary

An embodiment of the invention is directed to a bone marrow aspiration device comprising a plurality of syringes, each of which operates in a series of sequential steps to obtain bone marrow of high quality and therapeutic value, i.e., having a high mesenchymal stem cell (“MSC”) MSC/ml number. In certain embodiments, a syringe may be used along with a collection vessel or with a second syringe. A further embodiment of the invention is directed to a method for using the bone marrow aspiration device as set forth herein.