Decalcified Bone Matrix Scaffold with Bio-Gel for Pore Control
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Solution Overview
Problem
Current tissue engineering scaffolds for hard tissue repair lack suitable pore size control and mechanical strength, leading to inefficient cell loading and regeneration issues.
Innovation Solution
A tissue engineering scaffold comprising a hard large aperture frame structure filled with degradable bio-gel, such as gelatin or collagen, which can be adjusted for pore size and mechanical strength, using a decalcified bone matrix or PCL framework, to effectively load cells and provide mechanical support for tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If sponge like porous scaffolds are used, then cell inoculation needs are met through adjustable pore sizes, but mechanical strength becomes unsatisfactory and cannot meet immediate repair requirements
Solution Approach 1:
The patent combines two different scaffold types into a composite structure: a decalcified bone matrix framework (providing mechanical strength) filled with porous sponge-like material (providing cell loading capability). This merging allows both contradictory requirements to be satisfied simultaneously - the framework provides structural support while the porous filling material enables effective cell inoculation.
Solution Approach 2:
The scaffold uses composite materials consisting of decalcified bone matrix (natural biomaterial with good mechanical properties) and porous sponge-like material (synthetic or natural polymer with controlled porosity). This composite approach allows the scaffold to exhibit both high mechanical strength and suitable pore characteristics for cell loading.
2Strength
If decalcified bone matrix is used, then mechanical strength requirements are met, but pore size cannot be accurately controlled leading to low cell seeding efficiency
Solution Approach 1:
The patent applies local quality by having different regions of the scaffold with different properties: the decalcified bone matrix framework provides mechanical strength while the porous material filling the framework provides controlled pore sizes for cell loading. Each region is optimized for its specific function, resolving the contradiction between strength and pore size control.
3Productivity
If pore size is increased to improve cell loading, then cell seeding efficiency improves, but mechanical strength decreases and cannot meet immediate repair requirements
Solution Approach 1:
The scaffold merges a mechanical framework (decalcified bone matrix) with a porous cell-loading material, allowing the framework to bear mechanical loads while the porous material provides large surface area and suitable pore sizes for high cell seeding efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The scaffold achieves precise control over pore size and mechanical strength, enabling effective cell loading and successful regeneration of cartilage-like tissue, addressing the limitations of existing scaffolds by providing a suitable environment for tissue repair.
Implementation Method 1
the hard large aperture frame structure is selected from the group consisting of a decalcified bone matrix, a PCL framework, and a combination thereof
Data Source
AI summary
The present invention provides a tissue engineering scaffold. Specifically, the tissue engineering scaffold is a bio-gel-frame structure complex manufactured by uniformly filling a degradable bio-gel in a hard large aperture frame structure. The tissue engineering scaffold of the present invention optimizes the aperture of a conventional large aperture frame structure and improves the cell inoculation efficiency. In addition, the present invention also provides a preparation method for the novel tissue engineering scaffold and a use thereof in repairing hard tissue defects.