Bone Particle Composition with Interconnecting and Irregular Shapes
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current bone graft compositions lack sufficient strength, resorption rate, and incorporation/remodeling capabilities, and fail to effectively utilize varying concentrations and shapes of bone particles to enhance these properties.
Innovation Solution
A bone particle composition comprising a biologically-resorbable cement combined with processed bone particles of interconnecting and irregular shapes, where the interconnecting particles enhance mechanical properties and bioconnectivity, while irregular particles increase remodeling capabilities without compromising strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If allograft and xenograft materials are used to increase quantity of graft material, then the quantity of available bone material is improved, but disease transmission and graft failure risks increase
Solution Approach 1:
The patent applies parameter changes by controlling the particle size distribution (bimodal or multimodal distribution with specific ranges), shape characteristics (interconnecting vs irregular), and mineral content (5-50% mineral by weight) of bone particles to optimize both quantity and reliability of the graft composition
Solution Approach 2:
The patent creates a composite bone graft composition combining processed bone particles with specific mechanical properties and biological activity, mixed with bone void filler materials, to achieve both sufficient quantity and high reliability without using allograft or xenograft materials
2Strength
If bone particles with high concentration are used to increase composition strength, then the mechanical strength is improved, but resorption rate and remodeling capability decrease
Solution Approach 1:
The patent applies local quality by creating regions with different particle characteristics within the composition - interconnecting particles provide structural strength in load-bearing regions, while smaller irregular particles facilitate resorption in areas needing remodeling, achieving both strength and high resorption rate simultaneously
Solution Approach 2:
The patent uses parameter changes by implementing a bimodal or multimodal particle size distribution with specific ranges (e.g., 0.5-2.0 mm for interconnecting particles, 0.1-0.5 mm for irregular particles) and controlling mineral content (5-50% by weight) to balance mechanical strength with resorption rate and remodeling capability
3Productivity
If only irregularly-shaped bone particles are used to increase remodeling capability, then resorption rate is improved, but mechanical strength and bioconnectivity decrease
Solution Approach 1:
The patent applies local quality by assigning different functional roles to different particle types within the composition - interconnecting particles with larger size and higher mineral content provide mechanical strength and structural integrity, while irregular particles with smaller size facilitate resorption and remodeling, achieving both strength and high remodeling capability
Solution Approach 2:
The patent creates a composite particle system combining interconnecting bone particles (providing strength) with irregular bone particles (providing remodeling capability), where the synergistic interaction between different particle types achieves superior overall performance compared to using either particle type alone
Data Source
Figure 1A~1C
Figure 1D~1E
Figure 1F~1G
AI summary
Bone particle compositions and kits are provided that include a biologically-resorbable cement and a plurality of processed bone particles. A first portion of the processed bone particles in the compositions have a shape configured to interconnect with one another, while a second portion of the processed bone particles having an irregular shape. Methods for treating a bone defect are also provided wherein an effective amount of the bone particle compositions are administered to a site of a bone defect in a subject.