Bone Putty Using PEG and Bioactive Glass for Void Filling
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Solution Overview
Problem
Current bone putty materials are inadequate in providing a stable, viscous, and biocompatible filler for bone defects, often failing to securely attach bone repair devices and interfering with healing due to their viscosity and composition, which can cause inflammation and hinder bone growth.
Innovation Solution
A bone pore or void filling composition comprising a mixture of type I collagen, polyethylene glycol polymers with different molecular weights, tricalcium phosphate, and bioactive glass, which is highly lubricative and resorbs quickly to leave particles that induce and sustain bone growth, while being easy to handle and moldable for precise application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bone putty materials include ceramics or demineralized bone matrix to stimulate bone repair, then bone growth stimulation is improved, but the viscosity decreases and the ability to fill small bone pores is reduced
Solution Approach 1:
The patent employs a composite material formulation combining polyethylene glycol polymers (providing viscous putty consistency), tricalcium phosphate particles (50-300 microns, providing bone growth stimulation), and bioactive glass particles (50-300 microns, providing additional osteoconductivity). This composite approach allows each component to contribute its specific properties, achieving both high viscosity for pore filling and bone growth stimulation capabilities
Solution Approach 2:
The patent specifies precise parameter ranges to optimize performance: tricalcium phosphate particles sized 50-300 microns (optimal for pore filling while maintaining viscosity), bioactive glass at 3-7.5% by weight (provides stimulation without compromising putty consistency), and polyethylene glycol polymers with molecular weights of 350-650 g/mol and 1350-1650 g/mol (blend providing optimal viscous characteristics). These parameter controls ensure the material maintains both viscosity and bone growth stimulation
2Stability of the object's composition
If bone putty is made highly viscous to remain positioned inside bone, then positional stability is improved, but the ability to fill small bone pores is reduced
Solution Approach 1:
The patent creates local quality variations through a heterogeneous composite structure where tricalcium phosphate and bioactive glass particles (50-300 microns) are distributed within the polyethylene glycol matrix. This allows the material to exhibit different properties at different scales: macroscopically viscous for positional stability, but with fine particles capable of penetrating and filling small bone pores throughout the structure
Solution Approach 2:
The composite formulation inherently creates a porous structure through the particulate nature of tricalcium phosphate and bioactive glass dispersed in the polyethylene glycol matrix. This porous architecture allows the putty to adapt to and fill irregular bone defect geometries and small pores while maintaining overall structural integrity and positional stability
3Object-affected harmful factors
If bone putty uses materials like bone wax to control bleeding, then hemostatic effect is improved, but subsequent healing is interfered with and inflammation is caused
Solution Approach 1:
The patent achieves hemostasis through physical mechanisms inherent to the putty formulation rather than chemical action. The viscous polyethylene glycol matrix with embedded particulate materials provides mechanical tamponade and absorption of blood, achieving hemostatic effect without the inflammatory properties of bone wax. The biocompatible nature of polyethylene glycol, tricalcium phosphate, and bioactive glass ensures no inflammation or healing interference
Solution Approach 2:
The polyethylene glycol polymers in the formulation are designed to be temporarily present, providing hemostatic and structural functions during the critical early healing period, then gradually resorbing or being displaced by incoming bone tissue. This temporary presence achieves hemostasis without long-term interference with healing, unlike bone wax which persists and causes inflammation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively fills bone pores, provides a secure site for bone repair devices, controls bleeding, and promotes bone growth without causing adverse reactions, demonstrating biocompatibility and enhanced cohesiveness for prolonged implantation.
Implementation Method 1
The bone putty preferably provides various other features in addition to filling a bone void or defect... Earlier forms of bone putty, such as those based on bone wax, provide a useful hemostatic effect... The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights
Implementation Method 2
Earlier forms of bone putty, such as those based on bone wax, provide a useful hemostatic effect... The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights
Implementation Method 3
Some existing bone putty materials include materials such as ceramics or demineralized bone matrix that help stimulate bone repair... The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; tricalcium phosphate; and bioactive glass
Data Source
AI summary
A bone pore or void filling composition is described. The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; a bone growth stimulator; and bioactive glass. A kit for containing the bone pore or void filling composition, and methods for using the composition to fill a bone pore or void are also described.