Bone Regeneration Method Using Heated Chemical Solution
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing bone tissue regeneration methods involving immobilization with a plaster cast and introduction of specific aqueous solutions take a relatively long time to restore normal physiological function in injured bones.
Innovation Solution
The method involves heating the aqueous solution comprising 1-hydroxyethylidene diphosphonic acid, calcium chloride, gadolinium(III) nitrate, and dysprosium(III) chloride to 30° C.-100° C. for 1-48 hours before cooling it back to room temperature before injection into the bone fracture zone, significantly accelerating bone tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the aqueous solution is introduced directly at room temperature into the bone fracture zone, then the treatment procedure is simple, but the bone tissue regeneration time is relatively long
Solution Approach 1:
The aqueous solution is pre-heated to 30-100°C for 1-48 hours before injection into the bone fracture zone. This preliminary thermal treatment activates the biochemical components of the solution, enabling them to accelerate bone tissue regeneration more effectively when introduced into the injury site.
Solution Approach 2:
The temperature parameter of the aqueous solution is changed from room temperature to 30-100°C before injection. This parameter modification enhances the regenerative capability of the solution's components, thereby improving bone tissue regeneration speed without compromising the simplicity of the overall treatment approach.
2Loss of time
If the aqueous solution is heated to 30° C.-100° C. for 1-48 hrs. before injection, then the bone tissue regeneration time is reduced by 15-20%, but the treatment process becomes more complex
Solution Approach 1:
The aqueous solution undergoes preliminary heating treatment at 30-100°C for 1-48 hours before being injected into the bone fracture zone. This advance preparation activates the regenerative components in the solution, resulting in a 15-20% reduction in bone tissue regeneration time while maintaining manageable process complexity.
3Productivity
If the aqueous solution is heated and held at elevated temperature for extended periods, then the regeneration acceleration effect is enhanced, but the energy consumption increases
Solution Approach 1:
The temperature and time parameters of the heating process are optimized to achieve the maximum regeneration acceleration effect with reasonable energy input. The solution is heated to 30-100°C for 1-48 hours, allowing flexibility in balancing energy consumption against regenerative effectiveness based on specific clinical needs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces the bone tissue regeneration time by 15-20% and allows for faster restoration of normal physiological function compared to previous methods, with no noticeable toxicity or impact on the strength of the regenerated bone tissue.
Implementation Method 1
the aqueous Solution with pH 7.3-7.8 comprising 1.80-2.06 g/L of 1-hydroxyethylidene diphosphonic acid, 1.44-2.22 g/L of anhydrous calcium chloride, 0.30-0.40 g/L of gadolinium (III) nitrate hexahydrate, and 0.038-0.076 g/L of dysprosium (III) chloride hexahydrate is injected into the bone fracture Zone; however, prior to the injection thereof into the fracture Zone, said solution is brought to 30° C.-100° C., kept at said temperature for 1-48 hrs.
Implementation Method 2
prior to the injection thereof into the fracture Zone, said solution is brought to 30° C.-100° C., kept at said temperature for 1-48 hrs., and then brought back to room temperature
Data Source
AI summary
The invention relates to the treatment of different bone injuries, particularly fractures and fissure fractures. In order to reduce the time taken for bone tissue to regenerate at the site of damage, a method is used for regenerating bone tissue by fixing fragments of the damaged bone with a plaster cast or a bandage made of a polymer material and introducing into the fracture zone an aqueous solution containing 1-hydroxyethylidene diphosphonic acid in an amount of (1.80-2.06) g/l, anhydrous calcium chloride in an amount of (1.44-2.22) g/l, gadolinium (III) nitrate hexahydrate in an amount of (0.30-0.40) g/l and dysprosium (III) chloride hexahydrate in an amount of (0.038-0.076) g/l, with a pH of (7.3-7.8), wherein, prior to being introduced into the fracture zone, the above solution is brought to a temperature of (30-100°) C., is held at this temperature for (1-48) hours and is then cooled to room temperature.