Bone-Repair Composition Using Micro-Pulverized Matrix
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Solution Overview
Problem
Conventional bone-repair compositions using demineralized bone matrix have low bone growth factor release rates due to their highly cross-linked collagen network, and they are difficult to inject and maintain shape, requiring additional processing that can damage growth factors and collagen.
Innovation Solution
A bone-repair composition combining micro-pulverized and nonmicro-pulverized demineralized bone matrix with a hydrating material, which enhances injectability, shape-maintenance, and early release of bone growth factors without the need for additional separation processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If demineralized bone matrix is used in a powder state, then bone growth factors are trapped within the highly cross-linked collagen network and slowly released, but injectability and shape-maintenance are poor
Solution Approach 1:
The demineralized bone matrix is segmented into micro-particles (50-500 μm) through controlled pulverization, creating a dual-size particle system that maintains structural integrity for shape-maintenance while enabling better injectability and growth factor release
Solution Approach 2:
The physical parameters of the demineralized bone matrix are changed by controlling the particle size distribution through pulverization, transforming it from a coarse powder state to a fine micro-particle state with optimized characteristics for both bone repair efficacy and handling properties
2Productivity
If bone growth factors are separated from demineralized bone matrix, then early release is achieved, but multiple processing steps are required causing damage to growth factors and collagen
Solution Approach 1:
The invention extracts only the essential characteristic (particle size) from the demineralized bone matrix through controlled pulverization, eliminating the need for complex separation processes while preserving growth factors and collagen integrity
Solution Approach 2:
The demineralized bone matrix itself serves the dual function of providing structural framework and releasing growth factors through its micro-particle structure, eliminating the need for external separation processes or additional carriers
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition exhibits improved injectability, shape-maintenance, and bone-repair efficacy with early release of growth factors, maintaining biocompatibility and avoiding damage to growth factors and collagen, suitable for various bone fractures and necrosis treatments.
Implementation Method 1
a micro-pulverized demineralized bone matrix... exhibits excellent bone-repairing effects due to a large surface area of the micro-pulverized demineralized bone matrix
Implementation Method 2
a hydrating material... an early release of the bone growth factors
Data Source
AI summary
The present invention relates to a bone-repair composition comprising a micro-pulverized demineralized bone matrix; a nonmicro-pulverized demineralized bone matrix; and a hydrating material. The bone-repair composition of the present invention provides easier injectability and shape-maintenance (handling), and exhibits excellent bone-repairing effects due to a large surface area of the micro-pulverized demineralized bone matrix and an early release of the bone growth factors, compared with conventional compositions comprising the nonmicro-pulverized demineralized bone matrix alone. It also has an advantage of being biocompatible and harmless to the human body because there is no use of synthetic materials.