Bone Void Filler with Ceramic Beads for Sustained Release

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Solution Overview

Problem

Current bone repair materials face limitations such as donor site morbidity, immunogenic responses, high resorption rates, and inadequate stability, and existing synthetic materials have issues with workability, density, and therapeutic agent release.

Innovation Solution

A biodegradable bone void filler comprising a porous sponge matrix with ceramic cement beads loaded with a therapeutic agent, allowing for controlled and sustained release of the agent as new bone grows within the filler matrix.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If autologous cancellous bone is used for bone repair, then osteoinductive properties and non-immunogenicity are improved, but donor site morbidity and trauma increase

Engineering Contradiction:

Improveosteoinductive propertiesVSAvoiddonor site morbidity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention separates the desirable properties of autologous bone (osteoinductivity) from its drawbacks (donor site morbidity) by using bone morphogenetic proteins as isolated active ingredients that can be applied without harvesting autologous bone

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention extracts the key osteoinductive component (bone morphogenetic protein) from autologous bone and formulates it as a standalone therapeutic agent that can be delivered via ceramic beads, eliminating the need for donor site surgery

Inventive Principle:

Principle #2Taking out (Extraction)

2Adaptability or versatility

If allograft bone is used for bone repair, then availability is improved, but osteogenic capacity and revascularization decrease

Engineering Contradiction:

ImproveavailabilityVSAvoidosteogenic capacity

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The invention changes the material parameters by using synthetic ceramic beads (calcium sulfate, calcium phosphate, hydroxyapatite) with controlled porosity and degradation rates that promote osteogenesis without the limitations of allograft bone

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite system combining ceramic beads with bone morphogenetic protein and collagen sponge matrix, achieving superior osteogenic capacity compared to simple allograft bone

Inventive Principle:

Principle #40Composite materials

3Adaptability or versatility

If synthetic materials are used for bone repair, then availability and consistency are improved, but workability, handling and setting parameters deteriorate

Engineering Contradiction:

ImproveavailabilityVSAvoidworkability

Core Design Contradiction:

Adaptability or versatilityVSEase of operation

Solution Approach 1:

The invention uses porous ceramic beads that can be easily mixed with liquid carriers and applied to bone defects, improving workability while maintaining synthetic material advantages of availability and consistency

Inventive Principle:

Principle #31Porous materials

Solution Approach 2:

The invention optimizes the particle size, porosity, and chemical composition parameters of the ceramic beads to achieve optimal handling characteristics and setting properties for surgical application

Inventive Principle:

Principle #35Parameter changes

4Duration of action of moving object

If ceramic settable cements are used to trap therapeutic agents, then sustained release is improved, but porosity and bone grafting capability deteriorate

Engineering Contradiction:

Improvesustained releaseVSAvoidporosity

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The invention segments the therapeutic agent delivery system by loading antibiotics into porous ceramic beads separately, while the collagen sponge matrix provides the porous structure for bone ingrowth, combining sustained release with high porosity

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention creates a composite system where antibiotic-loaded ceramic beads are embedded in a porous collagen sponge matrix, achieving both sustained antibiotic release and high porosity for bone grafting

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides a stable and effective delivery of therapeutic agents, enhancing bone repair by minimizing immunogenic responses and improving the mechanical properties of bone void fillers, while allowing for controlled release of antibiotics to prevent infection.

Implementation Method 1

The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

ceramic cement beads comprising calcium sulfate and being biodegradable

Methodology Applied

Scientific EffectDissolution:

Implementation Method 3

a biodegradable matrix being a porous sponge and having ceramic cement beads comprising calcium sulfate and being biodegradable

Methodology Applied

Scientific EffectBiodegradation: Decomposition (biological)

Data Source

PatentEP3367974B1Bone void filler having calcium coatings

Publication Date: 2023.09.06 WARSAW ORTHOPEDIC INC

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AI summary

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.