Bone Void Filler Sustained Therapeutic Agent Release
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Solution Overview
Problem
Current bone repair materials face limitations such as donor site morbidity, immunogenic responses, high resorption rates, and inadequate stability, while synthetic materials often have issues with workability, density, and therapeutic agent release.
Innovation Solution
A biodegradable bone void filler comprising a porous sponge matrix with ceramic particles and cement beads loaded with a therapeutic agent, allowing for controlled and sustained release of the agent as new bone grows within the filler matrix.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ceramic settable cements are used to trap and release therapeutic agents, then therapeutic agent release is achieved, but porosity is insufficient
Solution Approach 1:
The invention divides the bone void filler into distinct functional components: porous ceramic particles provide the porous structure for bone ingrowth, while separate cement beads provide the therapeutic agent release function. This segmentation allows each component to optimize its specific function without compromising the other, resolving the contradiction between porosity and therapeutic agent release capability
Solution Approach 2:
The invention creates a composite material system combining porous ceramic particles with cement beads loaded with therapeutic agents. The composite structure integrates the high porosity of ceramic materials with the therapeutic agent release properties of cement beads, achieving both high porosity and reliable therapeutic agent release simultaneously
2Reliability
If allograft bone is used as bone void filler, then osteogenic capacity is provided, but resorption rate is high and immunogenic response is increased
Solution Approach 1:
The invention changes the material parameters by using synthetic porous ceramic materials with controlled pore size, porosity, and mechanical properties to mimic natural bone. This allows optimization of osteogenic capacity while eliminating the immunogenic response associated with allograft bone, as the synthetic materials are biocompatible and non-immunogenic
3Adaptability or versatility
If synthetic materials are used as bone void fillers, then availability and consistency are improved, but workability, handling and setting parameters are unacceptable
Solution Approach 1:
The cement beads are designed to be injectable in a liquid or semi-liquid state that flows easily through the porous ceramic matrix, then set in place to provide structural support. This dynamic property change from fluid to solid state improves workability and handling while maintaining availability and consistency of the synthetic material
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable and effective delivery of therapeutic agents, enhancing bone repair by minimizing immunogenic responses and improving the mechanical properties of the bone void filler, while allowing for controlled release of antibiotics and promoting bone growth.
Implementation Method 1
The cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent
Implementation Method 2
These settable cements exist that trap therapeutics agents within them and then the therapeutic agents are released as the ceramic resorbs
Data Source
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AI summary
A bone void filler material is provided that is configured for sustained release of a therapeutic agent. The bone void filler material comprises a biodegradable matrix having ceramic particles and cement beads disposed within the matrix, the cement beads loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.