Borinic Ester Stabilization in Oral Care via pH Buffering
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Solution Overview
Problem
Borinic esters are unstable and insoluble in aqueous compositions, making them challenging to incorporate effectively into oral care products like dentifrice for antimicrobial purposes, as they hydrolyze and decompose, and have limited solubility in water and oils.
Innovation Solution
Stabilizing borinic esters by maintaining a pH above 7, using buffering agents, and incorporating them with solubilizing agents such as polyoxyethylene and polyoxypropylene polymers, which enhances their solubility and antimicrobial activity in oral care compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If borinic esters are incorporated into aqueous oral care compositions, then antimicrobial activity is achieved, but stability deteriorates due to hydrolysis and decomposition
Solution Approach 1:
The patent employs buffering agents as intermediary substances that mediate between the borinic ester and the aqueous environment. The buffer system (maintaining pH 7 or higher) acts as a protective intermediary that prevents direct hydrolytic attack on the borinic ester, thereby preserving its chemical stability while allowing it to remain in the aqueous oral care composition and exert its antimicrobial effect
2Reliability
If borinic esters are added to aqueous compositions, then antimicrobial function is provided, but solubility worsens due to limited water and oil solubility
Solution Approach 1:
The patent applies parameter changes by modifying the pH parameter of the aqueous composition (maintaining pH at 7 or higher) to enhance the solubility of borinic esters. This parameter change prevents the ester from precipitating or separating, allowing sufficient quantity to remain dissolved in the aqueous oral care composition while maintaining its antimicrobial function
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The approach results in stable, soluble, and effective antimicrobial borinic esters that can be used in oral care products to reduce bacteria, inhibit plaque, and treat dental caries and gingivitis, maintaining their antimicrobial activity and stability over time.
Implementation Method 1
Stabilizing borinic esters by maintaining a pH above 7, using buffering agents
Implementation Method 2
incorporating them with solubilizing agents such as polyoxyethylene and polyoxypropylene polymers, which enhances their solubility
Data Source
Figure 1(a)~1(b)
Figure 2
AI summary
A stabilized oral care composition comprising a borinic acid derivative, e.g., a borinic ester.