Boronic Acid Affinity Membranes for Diol Separation
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Solution Overview
Problem
Traditional purification methods for molecules, especially those involving chromatography, are often slow, costly, and difficult to scale, particularly when dealing with diol-containing compounds.
Innovation Solution
Development of a separation media comprising a support substrate with immobilized separation ligands that include an affinity group capable of binding diol groups, such as boronic acid or benzoxaborole, facilitating rapid and selective isolation of diol-containing molecules in membrane chromatography.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional purification methods using specialized resin columns are used, then separation specificity is improved, but cost increases and scalability deteriorates
Solution Approach 1:
The patent replaces traditional mechanical chromatography systems with a membrane-based separation system. The membrane contains embedded separation ligands that perform the separation function, eliminating the need for complex packed column machinery and enabling simpler, more scalable processing.
Solution Approach 2:
The invention uses a porous membrane structure with embedded separation ligands. The porous nature of the membrane allows for high surface area contact between the membrane and analyte, providing effective separation while maintaining flow rates suitable for scaling.
2Measurement precision
If traditional purification methods using specialized resin are used, then separation specificity is improved, but processing time increases
Solution Approach 1:
The patent replaces slow resin column chromatography with a membrane system that enables faster flow rates. The membrane structure allows for improved mass transfer and reduced residence times while maintaining separation specificity through the embedded affinity ligands.
3Measurement precision
If traditional purification methods are used, then separation capability is achieved, but cost increases
Solution Approach 1:
The patent employs a membrane system that can be manufactured at lower cost compared to specialized resin columns. The membrane structure with embedded ligands represents a more economical approach that reduces both material costs and operational expenses while maintaining separation capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed separation media enables efficient, rapid, and selective isolation of diol-containing molecules, overcoming the limitations of traditional methods by improving scalability and reducing costs.
Implementation Method 1
the affinity group is capable of forming a reversible covalent bond with the diol group
Implementation Method 2
The separation media of the present disclosure may be useful for isolation and/or concentration of molecules that include a diol. The separation media of the present disclosure may be used for separations in membrane chromatography.
Data Source
AI summary
Separation media that includes a support substrate and a plurality of separation ligands immobilized on the support substrate. The plurality of separation ligands include an affinity capable of binding to a diol of a target molecule. The affinity group includes a boronic acid or a benzoxaborole. Methods of making the separation media and methods of using the separation media.