Boswellic Acids and Vitamin B12 Topical Composition for Psoriasis
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Solution Overview
Problem
Current treatments for psoriasis, particularly plaque psoriasis, are either ineffective, costly, or have severe side effects, necessitating the development of more efficient and side-effect-free topical alternatives.
Innovation Solution
A skin care composition comprising 1-10% boswellic acids, 0.02-2% vitamin B12 or its derivatives, and optionally 2-20% carbamide, formulated as creams, lotions, or ointments, which synergistically reduce inflammation and nitrogen oxide levels to alleviate psoriasis symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments (steroid creams, immunosuppressive drugs) are used to treat psoriasis, then symptom control is achieved, but severe side effects and high cost occur
Solution Approach 1:
The patent combines boswellic acids and vitamin B12 into a single topical composition to achieve synergistic therapeutic effects. This merging of two active ingredients allows the treatment to address multiple aspects of psoriasis pathology simultaneously, improving symptom control while avoiding the severe side effects associated with conventional monotherapies like steroids or immunosuppressants
Solution Approach 2:
The invention creates a composite topical formulation containing boswellic acids (1-10%) and vitamin B12 (0.02-2%) with optional carbamide (2-20%). This composite material leverages the anti-inflammatory properties of boswellic acids and the DNA synthesis/metabolism functions of vitamin B12 to treat psoriasis effectively without the harmful side effects of conventional treatments
2Reliability
If conventional treatments are used for severe psoriasis, then some symptom relief is achieved, but treatment cost increases significantly
Solution Approach 1:
The patent employs naturally derived, cost-effective ingredients (boswellic acids from Boswellia resin and vitamin B12) that can be formulated into affordable topical treatments. This approach replaces expensive conventional therapies with a more economical composition that provides comparable or superior symptom relief without the high treatment costs associated with systemic immunosuppressants or phototherapy
3Reliability
If higher concentrations of boswellic acid are used in topical treatment, then treatment efficacy improves, but formulation stability and skin tolerance may deteriorate
Solution Approach 1:
The patent optimizes the concentration parameters of boswellic acids (1-10%) and vitamin B12 (0.02-2%) to achieve the desired therapeutic effect while maintaining formulation stability and skin tolerance. This parameter optimization ensures that the composition remains stable during storage and application, preventing degradation of active ingredients while delivering effective treatment
Solution Approach 2:
The inclusion of vitamin B12 acts as a synergistic mediator that enhances the therapeutic effect of boswellic acids at lower concentrations. This intermediary component works together with boswellic acids to improve treatment efficacy while reducing the need for high concentrations of either ingredient alone, thereby maintaining formulation stability
Data Source
AI summary
The present disclosure relates to a skin care composition comprising boswellic acids and vitamin B12 or derivatives thereof. The compositions can be advantageously used in a method of treatment of dermatological conditions, disorders or diseases, in particular psoriasis, more particularly plaque psoriasis.