Animal-Protein-Free Botulinum Toxin Composition for Longer Effect
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing botulinum toxin compositions containing animal proteins, such as BOTOX®, DYSPORT®, and XEOMIN®, have a duration of effect that lasts only about 3 months, necessitating frequent administrations, which is inconvenient and costly.
Innovation Solution
Development of an animal-protein-free botulinum toxin composition, formulated with polysorbate 20, methionine, and optionally isoleucine, which maintains stability and efficacy at room temperature, allowing for longer-lasting effects without the need for animal-derived stabilizers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If botulinum toxin compositions containing animal proteins are used, then stability and efficacy are maintained, but the duration of effect is limited to about 3 months
Solution Approach 1:
The patent removes animal proteins from the botulinum toxin composition formulation. The invention specifically formulates botulinum toxin without animal-derived stabilizers, thereby eliminating potential contaminants while extending the duration of effect from 3 months to at least 16 weeks.
Solution Approach 2:
The patent changes the chemical composition parameters of the botulinum toxin formulation by substituting animal protein stabilizers with alternative stabilizing agents. This parameter change in the formulation enables both extended duration of action and maintained stability without animal-derived components.
2Reliability
If botulinum toxin is administered frequently to maintain effect, then therapeutic outcomes are maintained, but treatment cost and inconvenience increase
Solution Approach 1:
By removing animal proteins from the formulation, the patent extends the duration of therapeutic effect, thereby reducing the frequency of required administrations and associated time loss for patients.
Solution Approach 2:
The patent achieves continuous therapeutic effect for at least 16 weeks through formulation improvements, eliminating gaps in therapeutic action and reducing the need for repeated administrations.
Data Source
AI summary
The invention relates to the use of an animal-protein-free botulinum toxin composition to treat a disease, disorder or condition in a patient in need thereof whereby the animal-protein-free botulinum toxin composition exhibits a longer lasting effect in the patient compared to an animal-protein-containing botulinum toxin composition.