Single-Injection Bovine Superovulation via Dual-Hormone Microspheres
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Solution Overview
Problem
Current superovulation protocols for bovine animals are inefficient due to the need for multiple injections of gonadotropins at specific timed intervals, causing stress to both animals and personnel, and resulting in variable embryo yields and increased costs.
Innovation Solution
A single-injection method using a dual-hormone protein microsphere matrix with a controlled release agent, which includes FSH and LH, to induce dominant follicle removal, stimulate follicular growth, and control ovulation, allowing for synchronous ovulation and embryo production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple injections of gonadotropins are administered at specific timed intervals, then follicular growth and ovulation can be induced, but animal and personnel stress increase and procedure complexity increases
Solution Approach 1:
The patent combines multiple gonadotropin hormones (FSH and LH) into a single injectable formulation containing both hormones. This merging of multiple hormone administrations into one injection resolves the technical contradiction by maintaining reliable follicular growth induction through combined FSH and LH action while eliminating the stress caused by multiple repeated injections of animals and personnel
2Reliability
If multiple injections of gonadotropins are administered at specific timed intervals, then follicular growth and ovulation can be induced, but procedure complexity and costs increase
Solution Approach 1:
The patent merges multiple hormone injections into a single combined FSH-LH formulation administered once. This resolves the procedure complexity by eliminating the need for multiple timed injections while maintaining reliable ovulation control through the synergistic action of both hormones in the single injection
Solution Approach 2:
The single injectable formulation serves multiple functions simultaneously: it provides both FSH for follicular stimulation and LH for ovulation induction. This multi-functionality resolves the technical contradiction by achieving comprehensive ovulation control in one administration, eliminating the complex multi-step injection protocol
3Productivity
If traditional superovulation protocols are used, then embryo production can be achieved, but embryo yields are variable and costs are increased
Solution Approach 1:
The patent changes the hormonal parameter composition by combining FSH and LH in a single formulation, creating a new hormonal profile that produces more consistent follicular development and ovulation responses. This parameter change resolves the technical contradiction by improving embryo yield consistency while maintaining high embryo production through optimized hormone synergy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method simplifies the superovulation process, reduces animal and personnel stress, and increases embryo yields by providing sustained hormone release, enabling more efficient and controlled follicular development and ovulation.
Implementation Method 1
A single-injection method using a dual-hormone protein microsphere matrix with a controlled release agent, which includes FSH and LH, to induce dominant follicle removal, stimulate follicular growth, and control ovulation
Data Source
AI summary
Methods and formulations for a simplified, single-injection method to induce and control the synchronous growth (superstimulation), and ovulation (superovulation) of multiple ovarian follicles in bovine, ovine, caprine, camelid and other female animals enabling the subsequent collection of (a) multiple oocytes when conducting in-vitro fertilization, or (b) multiple embryos when conducting multiple ovulation embryo transfer.