Boysenberry Apple Blackcurrant Composition Airway Remodelling
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Solution Overview
Problem
Current treatments for respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) do not effectively prevent airway remodelling, a progressive and irreversible decline in airway function characterized by structural changes in the airway walls, leading to inflammation and lung function loss.
Innovation Solution
Administration of a composition comprising Boysenberry and apple concentrate, or a combination of Boysenberry, apple, and blackcurrant concentrate, which acts as a nutraceutical to treat or prevent inflammation, asthma, COPD, and airway remodelling by reducing collagen deposition and increasing matrix metalloproteinase-9 expression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current asthma and COPD medications are used to manage inflammation and control symptoms, then symptom severity and airflow obstruction are improved, but airway remodelling and fibrosis progression are not prevented
Solution Approach 1:
The patent applies preliminary action by using fruit and vegetable extracts to prevent airway remodelling and fibrosis before they become irreversible structural changes. The composition is administered to inhibit profibrotic cytokine release and MMP-9 activation in advance, preventing the progression from inflammation to permanent tissue damage, while current medications simultaneously manage acute symptoms
2Object-affected harmful factors
If polyphenol-rich fruits and vegetables are consumed to reduce inflammation, then respiratory health may be improved, but the specific mechanism for preventing fibrosis and remodelling remains unknown
Solution Approach 1:
The patent employs feedback by measuring MMP-9 activity and profibrotic cytokine levels to evaluate the effectiveness of the fruit and vegetable extract composition. This biomarker-based feedback mechanism provides objective evidence that the polyphenols are actively preventing fibrosis and remodelling, transforming the previously unknown mechanism into a measurable and verifiable process
3Object-generated harmful factors
If macrophage populations are depleted to reduce fibrosis, then lung fibrosis may be reduced, but the fibrolytic functions of macrophages that contribute to fibrosis resolution are lost
Solution Approach 1:
The patent applies local quality by selectively modulating macrophage function rather than depleting them. The fruit and vegetable extract composition induces a specific anti-inflammatory and antifibrotic macrophage phenotype that locally produces protective cytokines and inhibits profibrotic pathways, preserving the beneficial fibrolytic functions while eliminating the harmful fibrogenic effects
Data Source
AI summary
The present disclosure encompasses compositions prepared from Boysenberry and apple, as well as compositions prepared from Boysenberry, apple and blackcurrant. Also encompassed are methods of preparing these compositions and methods of using these compositions, in particular, for treating or preventing disorders of the respiratory system, including amongst others: inflammation, asthma, chronic obstructive pulmonary disease, allergic airways inflammation, reactive airway disease, airway fibrosis, and airway remodelling.