Bradykinin Receptor Antagonist Compositions for Urinary Bladder Pain
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Solution Overview
Problem
Existing treatments for conditions associated with bradykinin receptor overactivity, such as pain, inflammation, and urinary bladder disorders, are inadequate in providing effective relief.
Innovation Solution
Development of pharmaceutical compositions comprising bradykinin receptor antagonists, including compounds I, II, III, IV, and V, and their pharmaceutically acceptable salts and solvates, administered via various routes to target bradykinin receptors and alleviate associated symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for bradykinin receptor overactivity are used, then existing therapeutic options are available, but effective relief is inadequate
Solution Approach 1:
The patent introduces bradykinin receptor antagonists as intermediary compounds that block the interaction between bradykinin and its receptors. These compounds (I, II, III, IV, V and their salts/solvates) act as mediators to prevent the harmful signaling cascade initiated by bradykinin overactivity, thereby providing effective relief from pain, inflammation, and urinary bladder disorders without directly eliminating bradykinin itself
Solution Approach 2:
The patent employs multiple chemical compounds with varying structures (different R1, R2, R3 substituents) to optimize receptor binding affinity and selectivity. By changing chemical parameters of the antagonist molecules, the invention achieves enhanced therapeutic effectiveness and relief from symptoms that current treatments cannot adequately address
2Ease of operation
If bradykinin receptor antagonists are administered, then pain and discomfort are reduced, but the complexity of pharmaceutical composition increases
Solution Approach 1:
The patent develops a series of bradykinin receptor antagonists (compounds I, II, III, IV, V and their pharmaceutically acceptable salts and solvates) that can address multiple symptoms (pain, burning, urgency, frequency, discomfort) and multiple conditions (Interstitial Cystitis, chronic pelvic pain, inflammation) through a single mechanism of action - blocking bradykinin receptors. This multi-functional approach simplifies treatment despite the complexity of the pharmaceutical compositions
Data Source
AI summary
The present invention relates to compounds useful as bradykinin receptor antagonist, pharmaceutical composition comprising such compounds, and therapeutic use of the same. The present invention further relates to the combination of compounds useful for the therapeutic use. The present invention relates to the pharmaceutical composition comprising the compound and combination of compounds useful for treatment of urinary bladder pain, the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters.