3D Brain Biopsy Path Planning With External Coordinate Registration

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Solution Overview

Problem

Conventional neurosurgery relies on subjective judgment of neurosurgeons to determine surgical paths, leading to varying degrees of brain damage due to different surgical paths through cerebral tissues.

Innovation Solution

Integrate an external coordinate system with a brain model to generate a biopsy path using modules for image obtaining, registration, signal extraction, model construction, coordinate system definition, path calculation, and display to objectively determine an optimal biopsy path.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If neurosurgeons use subjective judgment to determine surgical paths, then surgical flexibility and adaptability are maintained, but the precision and objectivity of path selection deteriorates

Engineering Contradiction:
Improvepath selection precisionVSAvoidsurgical planning system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The surgical planning system segments the brain into different tissue types (gray matter, white matter, cerebral tissues) and calculates multiple path parameters (path distance, tissue volumes, vascular intersections) separately, then integrates them for comprehensive path evaluation. This segmentation enables precise, objective comparison of different surgical paths without requiring complex manual assessment.

Inventive Principle:
Principle #1Segmentation

2Reliability

If multiple surgical paths are considered to minimize brain damage, then the quality of surgical outcome improves, but the time required for surgical planning increases

Engineering Contradiction:
Improvesurgical outcome qualityVSAvoidsurgical planning time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The system replaces manual surgical path assessment with automated computer-based calculation. The path calculation module automatically computes multiple path parameters including path distance, volume of gray matter, white matter, arteries, and veins intersected, eliminating time-consuming manual evaluation while enabling comprehensive comparison of multiple surgical paths to identify the optimal route.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system creates a 3D virtual model (copy) of the patient's brain based on medical images, allowing multiple surgical paths to be simulated and evaluated in the virtual model before actual surgery. This copying approach enables thorough planning without extending actual surgical time, as all calculations are performed preoperatively.

Inventive Principle:
Principle #26Copying

3Manufacturing precision

If 3D models and coordinate systems are integrated to enable precise biopsy path calculation, then manufacturing precision of surgical plan improves, but device complexity increases

Engineering Contradiction:
Improvebiopsy path calculation precisionVSAvoidcoordinate system integration complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The system introduces a coordinate system as an intermediary framework that bridges the 3D brain model and the physical surgical space. Marker points on the skin surface establish the coordinate system, which then maps biopsy coordinates to the 3D model, enabling precise calculation of biopsy paths. This intermediary structure simplifies the integration process by providing a standardized reference framework.

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentUS20260000457A1Device of integrating external coordinate system and brain model to generate biopsy path and method thereof
Publication Date: 2026.01.01 NAT YANG MING CHIAO TUNG UNIV
  • US20260000457A1 patent drawing
  • US20260000457A1 patent drawing
  • US20260000457A1 patent drawing

AI summary

A device of integrating an external coordinate system and a brain model to generate a biopsy path and a method thereof are disclosed. In the device, through registration of brain images of a target person, a registration integration image is generated, binary mask images of different cerebral tissues are extracted from the registration integration image, 3D models are reconstructed based on the binary mask images of the cerebral tissues, an external coordinate system on a skin surface model in the 3D models is established; after a target area in the 3D models is selected and a biopsy point is set, a biopsy path in the 3D models is calculated based on position information of the target area and a coordinate of the biopsy point in the external coordinate system, and the biopsy path in the 3D models is marked.