Brain-Function Image Augmentation via Parameter Space

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Solution Overview

Problem

Current nuclear medicine brain-function image data augmentation methods are inadequate due to subjective image interpretation, lack of standard procedures, and limited data availability, leading to inconsistent and unreliable diagnoses, especially in dementia diagnosis where data imbalance hampers deep learning models.

Innovation Solution

A brain-function image data augmentation method that involves creating a target database with nuclear-medicine images for different ages, calculating image-data ratios, establishing relationships using linear regression, and linearly combining estimated and ratio information to generate augmented data, addressing data shortages and improving deep learning model training.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If rigid body motions (rotations, displacements, scaling) are applied to augment nuclear-medicine brain-function image data, then the number of training samples increases, but physiological characteristics are lost

Engineering Contradiction:
Improvenumber of training samplesVSAvoidphysiological characteristics
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the augmentation approach from spatial transformations to parameter-space transformations. Instead of rotating or scaling images, it modifies the statistical parameters (mean and standard deviation) of the image data to generate augmented samples that preserve physiological characteristics while increasing data diversity for training.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If more nuclear medical images are collected to improve deep learning training, then data availability increases, but collection costs and time increase significantly

Engineering Contradiction:
Improvedata availabilityVSAvoidcollection time
Core Design Contradiction:
Quantity of substanceVSLoss of time

Solution Approach 1:

The patent creates copies of existing images through parameter-space transformations. By generating augmented samples from limited original images using statistical parameter modifications, it produces sufficient training data without the need to collect additional medical images, thus saving time and resources.

Inventive Principle:
Principle #26Copying

3Adaptability or versatility

If subjective image interpretation by physicians is used, then clinical experience can be applied, but reproducibility and consistency decrease

Engineering Contradiction:
Improveclinical experience applicationVSAvoidreproducibility
Core Design Contradiction:
Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent replaces the subjective human interpretation mechanism with an objective computational mechanism. By using standardized parameter-space augmentation and deep learning models trained on augmented data, it eliminates variability in human judgment while maintaining adaptability through learned patterns, thereby improving reproducibility and consistency.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentUS11369268B2Brain-function image data augmentation method
Publication Date: 2022.06.28 ATOMIC ENERGY COUNCIL INSTITUTE OF NUCLEAR ENERGY RESEARCH
  • US11369268B2 patent drawing

AI summary

A brain-function image data augmentation method includes: a step of providing a target database including a plurality of image-data information; a step of, based on a plurality of image-data expected information in an expectation-value database, calculating a ratio of the plurality of image-data expected information with respect to different ages; a step of, based on the plurality of image-data information and the ratio, obtaining image-data ratio information with respect to an estimated age; a step of establishing a relationship for each pair of the image-data information and the image-data expected information; a step of, based on the relationship, the ratio and the image-data information, calculating an estimated image-data information with respect to the estimated age; and, a step of combining linearly the estimated image-data information and the image-data ratio information so as to generate an augmented image-data information with respect to the estimated age.