Deep Brain Stimulation Control Using Movement Desynchronization
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Solution Overview
Problem
Existing electrical stimulation therapies for conditions like Parkinson's disease and tremor often deliver inconsistent therapy magnitudes, leading to insufficient treatment, excessive power consumption, and side effects due to constant stimulation levels that do not account for varying patient conditions and activities.
Innovation Solution
A system that adjusts electrical stimulation parameters based on a homeostatic window defined by sensed patient signals, maintaining therapy within therapeutic bounds to optimize treatment efficacy and reduce side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If constant stimulation levels are delivered, then reliable symptom treatment is achieved, but power consumption increases and side effects occur
Solution Approach 1:
The patent implements dynamic adjustment of stimulation parameters based on real-time sensing of patient physiological signals. The system transitions from constant stimulation to variable stimulation that adapts to changing patient conditions, using feedback loops to modulate amplitude, frequency, or pulse width according to sensed biomarkers indicating symptom severity.
Solution Approach 2:
The system incorporates feedback mechanisms where physiological signals from the patient are continuously monitored and used to adjust stimulation delivery. The sensed signals provide information about treatment efficacy and patient state, enabling closed-loop control that maintains symptom management while optimizing power consumption by reducing stimulation during periods of low symptom severity.
2Reliability
If constant stimulation levels are delivered, then symptom management is maintained, but side effects increase
Solution Approach 1:
The system dynamically adjusts stimulation intensity based on real-time patient response and physiological state, delivering higher stimulation only when symptom severity increases and reducing or暂停 stimulation when symptoms are well-controlled, thereby minimizing exposure to stimulation-related side effects while maintaining treatment reliability.
Solution Approach 2:
The patent employs parameter changes in stimulation delivery by modifying amplitude, frequency, pulse width, or electrode configuration based on sensed physiological signals. This allows the system to adapt stimulation characteristics to match patient needs, avoiding excessive stimulation that causes side effects while maintaining effective symptom control.
3Use of energy by moving object
If adaptive therapy is implemented, then power consumption is reduced and side effects decrease, but device complexity increases
Solution Approach 1:
The patent integrates multiple functions into a single implantable system, combining stimulation delivery, physiological signal sensing, signal processing, and adaptive parameter adjustment capabilities. This multi-functional approach reduces the need for separate devices and minimizes overall system complexity while enabling power-efficient adaptive therapy.
Solution Approach 2:
The system incorporates self-adjustment capabilities where the implanted device autonomously processes sensed signals and modifies stimulation parameters without requiring external intervention. This self-service functionality reduces the need for complex external programming and monitoring infrastructure, simplifying the overall system while maintaining adaptive power management.
Data Source
AI summary
Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes. The medical system determines a first change of a first sensed signal of the patient to movement by the patient and a second change of a second sensed signal of the patient to the movement by the patient. Based on the first change and the second change, the medical system selects one of the first sensed signal and the second sensed signal of the patient for controlling the electrical stimulation therapy. The medical system adjusts a level of at least one parameter of the electrical stimulation therapy based on the selected one of the first sensed signal and the second sensed signal.