Deep Brain Stimulation Control Using a Homeostatic Window
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Solution Overview
Problem
Existing electrical stimulation therapies for conditions like Parkinson's disease do not adapt to changing patient conditions, leading to insufficient treatment or excessive side effects due to constant magnitude delivery, and inefficient power consumption.
Innovation Solution
A system that adjusts electrical stimulation parameters based on a homeostatic window defined by lower and upper bounds, using sensed neurological signals to maintain therapy within therapeutic limits, reducing side effects and power consumption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If constant magnitude electrical stimulation therapy is delivered to treat Parkinson's disease, then therapeutic effect is maintained, but side effects increase and power consumption becomes inefficient
Solution Approach 1:
The patent implements dynamic adjustment of stimulation magnitude based on real-time monitoring of neurological signals and patient state. The system transitions from constant magnitude delivery to variable magnitude delivery, adapting the stimulation level to current patient needs while maintaining therapeutic effect and reducing side effects.
Solution Approach 2:
The system continuously monitors neurological signals (such as LFP or EEG) and uses this feedback to adjust the stimulation magnitude. The feedback loop compares the monitored signal against a homeostatic window and modifies stimulation parameters to maintain the signal within the therapeutic range, thereby optimizing both efficacy and safety.
2Reliability
If constant magnitude electrical stimulation therapy is delivered, then therapeutic effect is maintained, but power consumption increases
Solution Approach 1:
The system dynamically adjusts stimulation magnitude based on real-time patient state and neurological signal monitoring. By delivering stimulation only at the necessary magnitude to maintain therapeutic effect, the system significantly reduces power consumption compared to constant high-magnitude delivery.
Solution Approach 2:
The system changes stimulation parameters (magnitude, pulse width, frequency) based on the monitored neurological signals and patient response. This parameter adaptation allows the system to maintain therapeutic effect while optimizing power consumption by delivering lower magnitudes when sufficient.
3Adaptability or versatility
If electrical stimulation parameters are adjusted frequently to adapt to changing patient conditions, then therapeutic efficacy improves, but device complexity increases
Solution Approach 1:
The system uses automated feedback control based on monitored neurological signals to adjust stimulation parameters. This reduces the need for manual programming and complex clinician intervention, as the device autonomously adapts to changing patient conditions within predefined therapeutic windows.
Solution Approach 2:
The system performs self-adjustment of stimulation parameters based on real-time monitoring of patient state and neurological signals. The device automatically modifies its own operation to maintain therapeutic effect, reducing the burden on clinicians and simplifying the overall control architecture.
Data Source
AI summary
Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.