Multi-Site Brain Stimulation Therapy Target Selection
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Solution Overview
Problem
Current therapies for psychiatric disorders often fail to effectively target specific symptoms or mood states, leading to inadequate treatment outcomes, as existing methods do not allow for precise selection and stimulation of multiple brain tissue sites based on individual patient symptoms or mood states.
Innovation Solution
A method and system for selecting and delivering therapy to multiple target tissue sites within the brain using weighting factors, where electrodes are positioned to deliver electrical stimulation or therapeutic agents based on patient-specific symptoms or mood states, allowing for dynamic adjustment of therapy parameters such as intensity and frequency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single target tissue site is stimulated, then the therapy delivery is simple, but the treatment effectiveness for multiple symptoms is insufficient
Solution Approach 1:
The patent divides the brain into multiple target tissue sites (e.g., subcallosal cingulate cortex, anterior cingulate cortex, ventral striatum, amygdala, hippocampus) that can be independently stimulated. Each site addresses specific symptoms or mood states, allowing segmented treatment of complex psychiatric conditions rather than relying on a single stimulation target.
Solution Approach 2:
The patent introduces the dimension of multiple target tissue sites along the spatial axis, transitioning from single-site to multi-site stimulation. This dimensional expansion enables simultaneous addressing of multiple symptoms through coordinated stimulation of different brain regions, enhancing treatment comprehensiveness.
2Adaptability or versatility
If therapy parameters are fixed, then the programming is simple, but the adaptability to individual patient symptoms is insufficient
Solution Approach 1:
The patent implements dynamic therapy delivery by allowing clinicians to independently adjust stimulation parameters (amplitude, pulse width, frequency) for each target tissue site. The system transitions from static, fixed-parameter therapy to dynamic, customizable parameter control that adapts to individual patient symptom profiles and treatment responses.
Solution Approach 2:
The patent applies local quality by allowing different therapy parameters to be assigned to different target tissue sites based on the specific symptoms they address. Each stimulation site can have customized amplitude, pulse width, and frequency settings optimized for its particular function and the symptoms it targets, rather than using uniform parameters across all sites.
3Reliability
If multiple target tissue sites are stimulated simultaneously, then the symptom coverage is comprehensive, but the energy consumption increases
Solution Approach 1:
The patent enables partial action by allowing clinicians to selectively activate only the necessary subset of target tissue sites based on the patient's specific symptom profile. Not all six potential targets need to be stimulated simultaneously; the system allows flexible activation of individual sites or combinations, delivering energy only where needed to address specific symptoms, thereby reducing overall energy consumption while maintaining effective symptom management.
Data Source
AI summary
Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.