Digital Architectural Map for Breast Tissue Imaging

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Solution Overview

Problem

Current methods for marking biopsy sites in breast tissue are inadequate, as foreign markers can be uncomfortable and difficult to locate during follow-up surgeries, with approximately 15% of markers being unfindable, and many biopsied lesions turn out to be benign, leading to unnecessary reminders and challenges in surgical navigation.

Innovation Solution

A system and method for creating a digital architectural map of breast tissue using combined imaging techniques such as x-ray, ultrasound, elastography, and Doppler, which records unique features like vascularity and stiffness patterns, allowing for virtual marking and navigation of biopsy sites during future procedures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If physical markers are embedded in biopsy sites, then the location can be identified during future imaging procedures, but the patient experiences discomfort and the markers may be difficult to locate during follow-up surgery

Engineering Contradiction:
Improvemarker location accuracyVSAvoidpatient discomfort
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent creates a digital copy (3D model) of the breast tissue and biopsy site location, replacing the physical marker with a virtual representation in a computational model. This digital twin allows surgeons to navigate to the biopsy site using the 3D model during surgery, eliminating the need for physical markers that cause patient discomfort while maintaining accurate location identification.

Inventive Principle:
Principle #26Copying

2Reliability

If physical markers are embedded in biopsy sites, then the location can be identified during future imaging procedures, but approximately 15% of markers cannot be located by surgeons for follow up surgery

Engineering Contradiction:
Improvemarker location accuracyVSAvoidsurgeon ability to locate marker
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent creates a digital copy (3D model) of the breast tissue and biopsy site location, replacing the physical marker with a virtual representation in a computational model. This digital twin allows surgeons to navigate to the biopsy site using the 3D model during surgery, eliminating the need for physical markers that cause patient discomfort while maintaining accurate location identification.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The patent transitions from two-dimensional imaging to three-dimensional modeling, creating a volumetric representation of the breast tissue that includes the biopsy site. This 3D model provides spatial context and depth information that improves surgeon navigation and location accuracy compared to traditional 2D imaging methods.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Measurement precision

If multiple imaging techniques are combined to create architectural map, then the precision of tissue characterization is improved, but the system complexity increases

Engineering Contradiction:
Improvetissue characterization accuracyVSAvoidimaging system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines multiple imaging modalities (ultrasound, MRI, CT, mammography) into a single integrated 3D architectural model. By merging these different imaging techniques, the system achieves comprehensive tissue characterization with improved precision while managing complexity through unified data processing and model integration.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a multi-functional imaging system that can perform multiple functions: visualizing tissue structure, characterizing tissue properties, locating biopsy sites, and guiding surgical navigation. This universal system handles diverse imaging tasks through a single integrated platform, managing complexity through shared processing architecture.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables accurate and comfortable virtual marking of biopsy sites, reducing the need for physical markers and improving the ability to locate them during surgeries, thus enhancing surgical precision and patient comfort.

Implementation Method 1

Ultrasound uses sound waves, typically produced by piezoelectric transducers, to image tissue in a patient. The reflected sound wave is detected by the transducers and converted into electrical signals that can be processed by the ultrasound scanner to form an ultrasound image of the tissue.

Methodology Applied
Scientific EffectPiezoelectric effect: Piezoelectric Effect

Implementation Method 2

Mammography and digital breast tomosynthesis (DBT) utilize x-ray radiation to visualize breast tissue.

Methodology Applied
Scientific EffectX-ray absorption: Absorption (EM radiation)

Implementation Method 3

measuring, using microflow Doppler, vascularity of the breast tissue including the region of interest

Methodology Applied
Scientific EffectDoppler effect: Doppler Effect

Implementation Method 4

measuring, using shear-wave elastography, stiffness of the breast tissue including the region of interest

Methodology Applied
Scientific EffectShear wave propagation: Shear Stress

Data Source

PatentUS20230098305A1Systems and methods to produce tissue imaging biomarkers
Publication Date: 2023.03.30 HOLOGIC INC
  • US20230098305A1 patent drawing
  • US20230098305A1 patent drawing
  • US20230098305A1 patent drawing

AI summary

Systems and methods for mapping a region of interest within breast tissue utilize multiple layers of information to produce a unique digital fingerprint of breast tissue. X-ray and ultrasound imaging is combined with elastography and Doppler to create an architectural map of a breast including coordinates to mark one or more regions of interest. The architectural map can be utilized during future imaging procedures and surgeries to automatically and virtually indicate the location of previously biopsied lesions. The architectural map can be displayed on a user interface of a computing device to guide a user to the region of interest during imaging.