Breath Sampling Mask with Graphene Sensors for VOC Detection

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Solution Overview

Problem

Current disease detection methods, particularly for diseases like cancers and chronic obstructive pulmonary disease, face challenges in accurately and early identifying volatile organic compounds (VOCs) in breath samples due to limitations in capturing and analyzing VOCs effectively.

Innovation Solution

A breath sampling mask system that captures and treats breath samples using porous and non-porous materials, filters, and chemical sensors, including graphene varactors, to detect VOCs, enabling accurate disease state determination by analyzing exhaled breath for specific compounds.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If breath sampling is performed using conventional methods, then the sampling process is simple, but the detection precision of VOCs is insufficient

Engineering Contradiction:
ImproveVOC detection precisionVSAvoidsampling system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines multiple functions (breath sampling, filtration, VOC detection) into an integrated mask system. The chemical sensors are embedded within the mask structure, merging the sampling device and detection device into a unified system that improves VOC detection precision while managing complexity through functional integration.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent employs porous materials in the mask structure to enable effective VOC capture from breath samples. The porous structure increases surface area for sensor contact and facilitates efficient gas permeation, thereby enhancing detection precision without requiring overly complex sampling mechanisms.

Inventive Principle:
Principle #31Porous materials

2Reliability

If chemical sensors are used to detect VOCs, then disease detection accuracy improves, but the device complexity increases

Engineering Contradiction:
Improvedisease detection reliabilityVSAvoidsensor system complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The chemical sensors in the mask are designed to detect multiple types of VOCs simultaneously, enabling the detection of various disease states (cancers, COPD, etc.) with a single sensor system. This multi-functionality improves disease detection reliability while avoiding the need for multiple separate detection devices.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent uses chemical sensors as intermediaries that convert VOC molecule interactions into measurable electrical signals. This intermediary mechanism enables reliable disease detection by translating chemical information into quantifiable data that can be analyzed for diagnostic purposes.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If breath samples are captured and treated with filtration, then VOC analysis accuracy improves, but the sampling time increases

Engineering Contradiction:
ImproveVOC analysis accuracyVSAvoidsampling time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The mask performs preliminary filtration and conditioning of breath samples as they are captured, removing interfering substances before VOC analysis. This preliminary action ensures that the VOC detection occurs on pre-conditioned samples, improving analysis accuracy without requiring separate post-sampling treatment steps that would extend total sampling time.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively captures and analyzes VOCs in breath samples, providing a reliable mechanism for early disease detection, including cancers and other disorders, by pre-conditioning and filtering the air and using chemical sensors to identify specific compounds.

Implementation Method 1

The mask can include a porous and non-porous material, a filter, and a chemical sensor

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 2

air is drawn in through the nose and/or mouth and into the lungs. By its presence in close contact with moist internal tissues, the inspired air is warmed, humidified, and picks up volatile organic compounds

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 3

chemical sensors, including graphene varactors, to detect VOCs

Methodology Applied
Scientific EffectChemical sensing:

Implementation Method 4

The document US 2016/109440 A1 discloses a breath sampling device comprising graphene varactors

Methodology Applied
Scientific EffectGraphene-based sensing: Graphene

Implementation Method 5

By its presence in close contact with moist internal tissues, the inspired air is warmed, humidified, and picks up volatile organic compounds

Methodology Applied
Scientific EffectThermal transfer: Conduction (thermal)

Implementation Method 6

By its presence in close contact with moist internal tissues, the inspired air is warmed, humidified, and picks up volatile organic compounds

Methodology Applied
Scientific EffectHumidification: Absorption (physical)

Data Source

PatentEP3755220B1Breath sampling mask and system
Publication Date: 2022.08.10 BOSTON SCIENTIFIC SCIMED INC
  • EP3755220B1 patent drawingFigure 1~2
  • EP3755220B1 patent drawingFigure 3~4
  • EP3755220B1 patent drawingFigure 5~6

AI summary

Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling mask. The breath sampling mask can include a mask housing configured to cover a portion of the face of a patient. The mask housing can define a breath receiving chamber. The breath sampling mask can include a chemical sensor element in fluid communication with the breath sampling mask, where the chemical sensor element can include a plurality of discrete binding detectors. The chemical sensor element can interface with a breath sample collected through the breath sampling mask. Other embodiments are also included herein.