Breathing Apparatus Recirculating Exhaled PRP Aerosol

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Solution Overview

Problem

Current inhalation systems for respiratory disorders are inadequate as they suffer from inaccuracy in dose delivery, loss of administered drug, and side effects from bronchodilators and corticosteroids, and do not offer a cure for respiratory conditions.

Innovation Solution

The development of an inhalation system that recirculates exhaled platelet-rich plasma (PRP) solution, minimizing loss to the environment and increasing its availability to the patient, using a breathing apparatus with a rebreathing chamber and nebulizer to deliver PRP as a mist, which can be reused during inhalation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional inhalation systems use bronchodilators and corticosteroids to treat respiratory disorders, then symptom management is achieved, but side effects occur and no cure is provided

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention changes the fundamental parameter of treatment approach by transitioning from pharmacological intervention (bronchodilators and corticosteroids) to biological therapy using platelet-rich plasma. This parameter change eliminates the harmful side effects associated with traditional medications while providing potential curative effects through growth factor stimulation and tissue regeneration, directly resolving the contradiction between treatment effectiveness and side effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention extracts and eliminates the harmful components (bronchodilators and corticosteroids) from the treatment regimen, replacing them with a beneficial alternative (platelet-rich plasma). By removing the source of side effects while maintaining therapeutic capability through a different mechanism, the invention resolves the contradiction between achieving treatment goals and avoiding harmful effects

Inventive Principle:

Principle #2Taking out (Extraction)

2Productivity

If commercially available inhalers administer drugs to patients, then disease management is achieved, but drug loss to atmosphere occurs and dose accuracy is poor

Engineering Contradiction:

Improvedisease management efficiencyVSAvoiddrug loss

Core Design Contradiction:

ProductivityVSLoss of substance

Solution Approach 1:

The invention incorporates a rebreathing chamber that captures exhaled aerosol and redirects it back to the patient. This feedback mechanism ensures that any drug or PRP not absorbed during the first inhalation is not lost to the atmosphere but is instead recirculated and re-administered, eliminating substance loss while maintaining efficient disease management

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

Instead of discarding exhaled aerosol to the atmosphere as in traditional inhalers, the invention recovers the exhaled material through the rebreathing chamber and reintroduces it to the patient. This recovery process prevents drug loss and maximizes the utilization of the administered substance, resolving the contradiction between productivity and substance loss

Inventive Principle:

Principle #34Discarding and recovering

3Quantity of substance

If PRP is administered through nebulizer for inhalation, then delivery to lungs is achieved, but exhaled PRP is lost without recirculation

Engineering Contradiction:

ImprovePRP delivery amountVSAvoidexhaled PRP loss

Core Design Contradiction:

Quantity of substanceVSLoss of substance

Solution Approach 1:

The rebreathing chamber creates a feedback loop where exhaled PRP is captured and redirected back to the nebulizer inlet. This ensures continuous recirculation of the PRP solution, maximizing the quantity of substance delivered to the patient's lungs while minimizing loss, as any PRP not absorbed in one cycle is available for the next

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The invention maintains continuous useful action by ensuring that PRP is constantly recirculated through the rebreathing chamber rather than being lost. The system continuously processes and re-delivers the PRP solution, maximizing the therapeutic benefit from each administered dose and eliminating the waste that would occur with single-pass inhalation systems

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This system effectively increases the delivery of PRP to the lungs, reducing side effects associated with traditional treatments and providing a more efficient and effective method for managing and potentially curing respiratory disorders by stimulating healing and improving lung function.

Implementation Method 1

a breathing apparatus with a rebreathing chamber and nebulizer to deliver PRP as a mist

Methodology Applied

Scientific EffectNebulization: Aerosol

Data Source

PatentUS10034996B2Inhalation systems, breathing apparatuses, and methods

Publication Date: 2018.07.31 AMERICAN REGENERATIVE TECH

AI summary

Examples of the invention include inhalation systems, breathing apparatuses, and methods for administering a solution by inhalation to a patient. Example breathing apparatuses described herein may be configured to minimize loss of the solution to the environment. Additionally or instead, example breathing apparatuses may be configured to recirculate exhaled solution to increase an amount of the solution available to a patient while minimizing exhausted solution. In some examples, breathing apparatuses may deliver nebulized platelet rich plasma (“PRP”).