Brillouin-OCTA-Speckle Elastography for Synchronous Vessel Imaging
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Solution Overview
Problem
Current technologies lack the capability for high-resolution and rapid detection of blood vessel structure, elasticity, and blood flow velocity, which are crucial for early diagnosis and treatment of blood vessel diseases such as atherosclerosis and thrombosis.
Innovation Solution
A Brillouin-OCTA-speckle multi-mode elastography system that combines Brillouin scattering elastography, optical coherence tomography angiography, and speckle imaging to synchronously measure blood vessel elasticity and blood flow velocity, utilizing a Brillouin-OCTA sample scanning unit, a Brillouin scattering elastography system, an OCTA system, and a speckle detection system with a time sequence controller to generate and acquire signals for blood vessel distribution and flow velocity information.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple separate detection systems are used for blood vessel structure, elasticity, and blood flow velocity, then measurement comprehensiveness is improved, but device complexity and detection time increase
Solution Approach 1:
The patent combines Brillouin scattering elastography system, OCTA system, and speckle detection system into a single integrated multi-mode elastography system that shares common optical components including light source, scanning unit, and detection pathways. This merging approach enables simultaneous acquisition of blood vessel structure, elasticity, and blood flow velocity data through a single device, reducing overall system complexity while maintaining comprehensive measurement capabilities
Solution Approach 2:
The integrated system employs universal optical components that serve multiple functions: the same light source excites both Brillouin scattering and OCTA signals, the scanning unit directs beams for multiple measurement modes, and the detection system processes various signal types. This multi-functionality allows a single device to perform structure imaging, elasticity measurement, and blood flow velocity detection without requiring separate specialized equipment for each modality
2Measurement precision
If multiple separate detection systems are used for blood vessel structure, elasticity, and blood flow velocity, then measurement comprehensiveness is improved, but detection speed decreases
Solution Approach 1:
The system implements continuous simultaneous acquisition of multiple measurement modes through coordinated operation of Brillouin scattering, OCTA, and speckle detection channels. The time sequence controller synchronizes all three modalities to collect structure, elasticity, and blood flow data in real-time during a single scanning process, eliminating the need for sequential measurements and thereby maintaining high detection speed while achieving comprehensive measurement
3Measurement precision
If conventional detection methods are used, then device simplicity is maintained, but resolution and detection capability are insufficient
Solution Approach 1:
The system segments the detection functionality into three specialized modalities (Brillouin scattering for elasticity, OCTA for structure, and speckle for blood flow) that are integrated within a unified platform. Each modality contributes specific high-resolution measurement capabilities, and their combination provides comprehensive high-resolution detection of blood vessel properties that conventional single-mode systems cannot achieve
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables high-resolution measurement of blood vessel elasticity and structure, and wide-field blood flow velocity measurement, providing a scientific basis for early diagnosis and prevention of blood vessel diseases.
Implementation Method 1
Brillouin scattering is an inelastic scattering process, having the spectral characteristics closely related to the properties of the medium (such as the density, viscosity, elasticity modulus, etc.). Therefore, the Brillouin scattering elastography technology can be employed to measure the bulk elasticity modulus of the blood vessel.
Implementation Method 2
The optical coherence tomography angiography (OCTA) obtains the tomographic image of the blood vessel distribution in the depth direction, depending on low-coherence interference
Implementation Method 3
Different scattered lights has different optical path differences to the camera imaging plane, so that different scattered lights will form the random interference phenomenon on the image plane, which shows as a particle pattern having brightness changes in spatial distribution. The motion of scattered particles (red blood cells) causes the fluctuation of speckle intensity on the image plane.
Data Source
AI summary
Disclosed is a Brillouin-optical coherence tomography angiography (OCTA)-speckle multi-mode elastography system device, including a Brillouin-OCTA sample scanning unit, a Brillouin scattering elastography system, an OCTA system, a speckle detection system, and a time sequence controller. According to the present invention, advantages that the Brillouin scattering elastography system can perform high-resolution measurement on a bulk elasticity modulus, the OCTA system can perform high-resolution structure imaging, and the speckle detection system can perform wide-field blood flow velocity measurement are utilized to perform in-situ synchronous imaging on a blood vessel structure and elasticity distribution, and to quantify a blood flow velocity, so that scientific basis and technical support are provided for early diagnoses of clinical blood vessel diseases.